IMR Press / RCM / Volume 24 / Issue 4 / DOI: 10.31083/j.rcm2404096
Open Access Review
Role of LncRNAs in the Pathogenesis of Coronary Artery Disease
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1 Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan, China
2 Department of Cardiac Surgery, The First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan, China
*Correspondence: 49976790@qq.com (Xiangfeng Bai); wlq8360@163.com (Luqiao Wang)
These authors contributed equally.
Rev. Cardiovasc. Med. 2023, 24(4), 96; https://doi.org/10.31083/j.rcm2404096
Submitted: 18 September 2022 | Revised: 4 December 2022 | Accepted: 6 December 2022 | Published: 23 March 2023
Copyright: © 2023 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Coronary artery disease (CAD), caused by coronary artery occlusion, is a common cardiovascular disease worldwide. Long non-coding RNAs (lncRNAs) are implicated in the regulation of endothelial cell injury, angiogenesis, plaque formation, and other pathological mechanisms in CAD by acting on different cell types. Some lncRNAs are significantly upregulated in CAD patients; however, other lncRNAs are significantly downregulated. Differential expression of lncRNAs in CAD patients enables them to be exploited as potential biomarkers to evaluate disease progression and diagnosis/prognosis in CAD patients. In this study, we reviewed the role of lncRNAs in the development of different clinical subtypes of CAD.

Keywords
lncRNA
coronary artery disease
endothelial cells
cardiomyocytes
vascular smooth muscle cells
cardiac fibroblasts
diagnostic biomarkers
Funding
81860073/National Natural Science Foundation of China
82160439/National Natural Science Foundation of China
2019FE001(-138)/Special Foundation Projects of Joint Applied Basic Research of Yunnan Provincial Department of Science and Technology with Kunming Medical University
202001AT070039/Yunnan Provincial Department of Science and Technology
H-2018032/Yunnan Health Training Project of High Level Talents
60118260106/100 Young and Middle-aged Academic and Technical Backbones of Kunming Medical University
YNQR-QNRC-2019-006/Young Talents of Yunnan Thousand Talents Plan
RLQN20200002/Young Talents of Yunnan Thousand Talents Plan
ZX2019-03-01/Clinical Medical Center for Cardiovascular and Cerebrovascular Disease of Yunnan Province
Figures
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