†These authors contributed equally.
Academic Editors: Salvatore De Rosa and Matteo Bertini
Background: This systematic review and meta-analysis aimed at comparing
the midterm outcomes of perventricular device closure (PDC) with conventional
surgical repair (CSR) for VSD. Methods: PubMed, Cochrane Library, and
Web of Science databases were searched from January 1, 2005, to October 15, 2020,
for English or Chinese language studies comparing outcomes of PDC with CSR for
VSD. The midterm results were assessed as a primary outcome. A systematic review
and meta-analysis was performed under the frequentist frame with risk ratio (RR)
and 95% confidence interval (CI). Results: A total of 4381 patients
(PDC = 2016, CSR = 2365) from 15 studies were included. The pooled estimates of
success rate favored the CSR compared with the PDC (RR, 0.97; 95% CI, 0.96 to
0.99; p = 0.001). No significant differences in minor complications or
severe complications were found between the PDC and CSR (RR, 0.79; 95% CI, 0.50
to 1.23; p = 0.29; RR, 1.43; 95% CI, 0.74 to 2.75; p = 0.29).
The pooled estimates of residual shunts favored the PDC compared with the CSR
(RR, 9.07; 95% CI, 4.77 to 17.24; p