†These authors contributed equally.
Academic Editor: Carlo Briguori
Background: Neutrophil percentage
to albumin ratio (NPAR) has been shown to be correlated with the prognosis of
various diseases. This study aimed to explore the effect of NPAR on the prognosis
of patients in coronary care units (CCU). Method: All data in this study
were extracted from the Medical Information Mart for Intensive Care III
(MIMIC-III, version1.4) database. All
patients were divided into four groups according to their NPAR quartiles. The
primary outcome was in-hospital mortality. Secondary outcomes were 30-day
mortality, 365-day mortality, length of CCU stay, length of hospital stay, acute
kidney injury (AKI), and continuous renal replacement therapy
(CRRT). A multivariate binary logistic regression analysis was performed to
confirm the independent effects of NPAR. Cox regression analysis was performed to
analyze the association between NPAR and 365-day mortality. The curve in line
with overall trend was drawn by local weighted regression (Lowess). Subgroup
analysis was used to determine the effect of NPAR on in-hospital mortality in
different subgroups. Receiver operating characteristic (ROC) curves were used to
evaluate the ability of NPAR to predict in-hospital mortality.
Kaplan–Meier curves were constructed to
compare the cumulative survival rates among different groups. Result: A
total of 2364 patients in CCU were enrolled in this study. The
in-hospital mortality rate increased significantly as the NPAR quartiles
increased (p