IMR Press / RCM / Volume 22 / Issue 2 / DOI: 10.31083/j.rcm2202045
Open Access Review
Atrioventricular synchronous leadless pacemaker: state of art and broadened indications
Show Less
1 Department of Cardiology, Luigi Sacco University Hospital, Via G.B Grassi 74, 20157 Milan, Italy
2 Department of Cardiology, Spedali Civili Hospital, University of Brescia, P.zza Spedali Civili 1, 25123 Brescia, Italy
*Correspondence: (Gianfranco Mitacchione)
Rev. Cardiovasc. Med. 2021, 22(2), 395–401;
Submitted: 10 April 2021 | Revised: 2 May 2021 | Accepted: 14 May 2021 | Published: 30 June 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Leadless pacemakers (LLPMs) have become a major breakthrough in the management of bradyarrhythmia as an attractive alternative to the standard transvenous pacemakers (TV-PMs). Recently, the introduction of a second-generation LLPMs (Micra AV-MC1AVR1) has expanded pacing modes to obtain atrioventricular (AV) synchronous pacing, providing an interesting alternative in the actual scenario of leadless pacing. Nevertheless, actual reports have highlighted some concerns regarding those devices. In this review, we sought to provide an overview of this technology based on its approval studies and major reports.

Leadless pacemakers
Atrioventricular synchrony
Atrioventricular synchronous leadless pacemaker
Fig. 1.
Back to top