Cardiopulmonary bypass (CPB) may trigger organs damage, including kidney injury,
due to a massive cytokine release. In this observational, prospective study, we
analyzed the possible impact of chronic treatment with ACE-Inhibitors (ACE-I) on
the inflammatory response and renal function after CPB. Sixty-nine
patients undergoing major cardiac surgery with CPB were enrolled. Patients were
stratified according to long-term (
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Antecedent ACE-inhibition, inflammatory response, and cardiac surgery associated acute kidney injury
Pierangela Presta1,*, Davide Bolignano1, Giuseppe Coppolino1, Filiberto Serraino2, Pasquale Mastroroberto2, Michele Andreucci1, Giorgio Fuiano1
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1
Nephrology and Dialysis Unit, “Magna Graecia” University, 88100 Catanzaro, Italy
2
Cardiac Surgery Unit, “Magna Graecia” University, 88100 Catanzaro, Italy
Rev. Cardiovasc. Med. 2021, 22(1), 207–213;
https://doi.org/10.31083/j.rcm.2021.01.288
Submitted: 21 December 2020 | Revised: 17 February 2021 | Accepted: 19 February 2021 | Published: 30 March 2021
Abstract
Keywords
ACE-inhibitors
Cardiopulmonary bypass
Kidney function
Acute kidney disease
Cytokines