IMR Press / RCM / Volume 22 / Issue 1 / DOI: 10.31083/j.rcm.2021.01.214
Open Access Review
Transcatheter mitral valve repair with MitraClip in patients with pulmonary hypertension: hemodynamic and prognostic perspectives
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1 Division of Cardiology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy
2 Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland
3 Division of Cardiology and Cardiac Intensive Care Unit, San Paolo Hospital, 17100 Savona, Italy
4 Cardiocentro Ticino, 6900 Lugano, Switzerland
5 Interventional Cardiology Unit, Cardio-Thoraco Vascular Department (DICATOV), IRCCS Ospedale Policlinico San Martino, Genova, Italy; IRCCS Italian Cardiovascular Network & Department of Internal Medicine, University of Genova, 16122 Genova, Italy
6 National Kapodistrian University of Athens, Medical School, 106 71 Athens, Greece
7 University of Iowa, Section of Advanced Heart Failure and Transplantation, Iowa City, IA 52242, USA

These authors contributed equally.

Rev. Cardiovasc. Med. 2021, 22(1), 33–38;
Submitted: 18 January 2021 | Revised: 11 March 2021 | Accepted: 12 March 2021 | Published: 30 March 2021
Copyright: © 2021 The Authors. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Transcatheter mitral valve repair with MitraClip has emerged as a possible therapeutic option for patients with severe mitral regurgitation (MR) with high risk for surgical valve repair. MitraClip intervention has demonstrated to improve haemodynamics and clinical outcomes in selected patients in observational and randomized studies. Preoperative pulmonary hypertension (PH) is known to affect prognosis in patients undergoing surgical mitral valve intervention. The aim of the present review is to discuss the available literature focused on the haemodynamic and clinical effects of MitraClip in patients with severe MR and PH.

Pulmonary hypertension
Mitral valve reurgitation
Fig. 1.
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