Pacemakers are more commonly recommended than theophylline for sick sinus
syndrome (SSS) treatment. The positive effects of cilostazol on bradyarrhythmias
also have been reported. However, no comparison of cilostazol and theophylline
has been previously reported found. We retrospectively enrolled SSS patients, who
refused a pacemaker implantation. Theophylline or cilostazol was administered,
and the heart rate (HR) was evaluated in 4-8 weeks using a digital
sphygmomanometer and the electrocardiogram (ECG). A 200-400 mg of theophylline
or 100-200 mg of cilostazol were administered per day in 50 and 30 patients,
respectively. The baseline HR was 54.8
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Positive chronotropic effects of theophylline and cilostazol in patients with symptomatic sick sinus syndrome who have declined permanent pacing
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1
Department of Cardiovascular Medicine, Heart Center of Chonnam National University Hospital, Chonnam National University Medical School, Chonnam National University, 671 Jeabongro, Dong-gu, Gwangju 61469, Korea
*Correspondence: yoonnamsik@gmail.com (Namsik Yoon)
Rev. Cardiovasc. Med. 2020, 21(3), 473–480;
https://doi.org/10.31083/j.rcm.2020.03.22
Submitted: 25 March 2020 | Revised: 1 May 2020 | Accepted: 4 June 2020 | Published: 30 September 2020
Copyright: © 2020 Jin et al. Published by IMR Press.
This is an open access article under the CC BY-NC 4.0 license (https://creativecommons.org/licenses/by-nc/4.0/).
Abstract
Keywords
Sick sinus syndrome
cilostazol
theophylline
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