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Cite this article
Managing the High-Risk Patient: Experience with Fenoldopam, a Selective Dopamine Receptor Agonist, in Prevention of Radiocontrast Nephropathy During Percutaneous Coronary Intervention
1 Cardiac Catheterization Laboratory of the Cardiovascular Institute,Mount Sinai School of Medicine, New York, NY
Rev. Cardiovasc. Med. 2001, 2(S1), 19–25;
Published: 20 January 2001
Acute worsening of renal function due to contrast agents occurs in 15% to 40% of patients with baseline renal insufficiency undergoing percutaneous coronary intervention. Radiocontrast nephropathy is associated with increased morbidity, prolonged hospitalization, and higher in-hospital mortalit y. Our nonrandomized data suggest that in adequately hydrated patients, the dopamine-1 receptor agonist fenoldopam is a useful adjunct during PCI for prevention of RCN, reducing its incidence to less than 5%. This renoprotective effect of fenoldopam was more pronounced in diabetics, with moderate renal failure, in whom no agent has been shown so far to be beneficial.
Radiographic contrast nephropathy
Percutaneous coronary intervention
Chronic renal insufficiency