IMR Press / RCM / Volume 18 / Issue 1 / DOI: 10.3909/ricm0825

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Cardiac Contractility Modulation: A Technical Guide for Device Implantation
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1 Medical Department, University of Heidelberg, Mannheim, Germany
2 German Centre for Cardiovascular Research (DZHK), Mannheim, Germany
3 Medizinische Klinik II, Kardiologie und Angiologie, Bergmannsheil Bochum, Universitätsklinik der Ruhr Universität Bochum, Bochum, Germany
4 Department of Cardiology and Intensive Care Medicine, Eichsfeld Klinikum, Leinefelde-Worbis, Germany
5 Department for Electrophysiology and Rhythmology, Clinic for Internal Medicine III, University of Schleswig-Holstein, Kiel, Germany
6 Impulse Dynamics, Hod Hasharon, Israel
Rev. Cardiovasc. Med. 2017, 18(1), 1–13;
Published: 30 March 2017
This article provides a technical description of common implant practice for delivery of cardiac contractility modulation (CCM) therapy to heart failure patients. As of September 2016, the authors of this article collectively have been involved with more than 400 system implantations in five medical centers, beginning with the advent of CCM therapy approximately 12 years ago. CCM therapy has been evaluated in a variety of studies, and was shown to be safe and effective and of benefit to patient quality of life and exercise capacity. As the use of CCM therapy continuously expands among medical centers in Europe, this article describes the technical and practical aspects of the implant procedure, and additional special technical cases based on our cumulative experience.
Heart failure
Cardiac contractility
Cardiac contractility modulation
Implantable pulse generator
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