IMR Press / RCM / Volume 15 / Issue S1 / 10.3908/ricm15S1S002

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Epidemiology of Coronary Heart Disease in Patients With Human Immunodeficiency Virus
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1 Divisions of Infectious Diseases and General Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA
Rev. Cardiovasc. Med. 2014, 15(S1), 1–8;
Published: 20 January 2014
As a growing number of patients infected with human immunodeficiency virus (HIV) have access to antiretroviral therapy and achieve virologic suppression, the focus of clinical care is shifting from treating the infectious complications of advanced immunodeficiency to managing and preventing chronic disease. The aging of the HIV-positive population and increased rates of chronic disease complications in the setting of HIV infection have increased the impact of noncommunicable diseases such as coronary heart disease (CHD). The effect of HIV on CHD is independent of traditional cardiovascular risk factors and antiretroviral medications and is likely due in part to the chronic inflammation and immune activation underlying HIV infection. This article describes the current state of epidemiologic knowledge on CHD in HIV infection. It highlights key studies in the field and summarizes epidemiologic data with respect to traditional and novel CHD risk factors, specialized clinical subgroups, and broader cardiovascular outcomes.
Human immunodeficiency virus
Coronary heart disease
Antiretroviral therapy
Risk factors
Cardiovascular disease
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