Reproductive function abnormalities in males with obesity, metabolic syndrome and type 2 diabetes: a two-way street
The epidemic of obesity and metabolic syndrome has resulted in a stressful impact on health systems worldwide. There is currently considerable effort in both the clinical and research settings to reduce the burden of associated health complications such as coronary heart disease, heart failure and stroke. However, these are also associated with other conditions that are often not recognized and/or undertreated, such as reproductive function abnormalities. In males, these complications severely affect quality of life, but their diagnosis and treatment are often inadequate.
Obesity and type 2 diabetes promote an array of abnormalities, with erectile dysfunction, hypogonadism and infertility being amongst the most common. Furthermore, high BMI is associated with urological manifestations, with weight gain putting patients at a higher risk of developing lower urinary tract symptoms. Prostate activity also seems to be impaired in obese patients, with some showing abnormal semen quality and retrograde ejaculation.
Interestingly, there is growing evidence to suggest the relationship between reproductive and metabolic abnormalities is bidirectional, with impaired hormonal synthesis/activity independently promoting the development of metabolic syndrome and type 2 diabetes. This was suggested from studies reporting that patients undergoing androgen deprivation therapy for metastatic prostate cancer were at high risk of developing type 2 diabetes. Other studies showed an amelioration of the associated metabolic abnormalities in hypogonadal patients treated with testosterone replacement therapy. Furthermore, newly developed therapies for metabolic disturbances have also shown some potential for improving reproductive health.
In light of the above findings, this research area deserves further investigation in order to provide novel strategies for improving men’s health and quality of life. This Special Issue presents recent research aimed at clarifying the interconnection between reproductive function abnormalities and obesity, metabolic syndrome and type 2 diabetes in men. Hence, the topic of submitted papers may not be limited to the reported keywords listed below.
Angelo Di Vincenzo
Manuscripts should be submitted via our online editorial system at https://jour.ipublishment.com/imr/access/login by registering and logging in to this website. Once you are registered, click here to start your submission Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1500 USD. Submitted papers should be well formatted and use good English.