IMR Press / JOMH / Volume 18 / Issue 7 / DOI: 10.31083/j.jomh1807150
Open Access Original Research
Daily Dose of 5 mg Tadalafil Safely Improves Erectile Function and Liver Function Enzymes in Smokers
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1 Department of Family Medicine, Soonchunhyang University Hospital Seoul, 04401 Seoul, Republic of Korea
*Correspondence: (Byung Wook Yoo)
J. Mens. Health 2022, 18(7), 150;
Submitted: 16 November 2021 | Revised: 17 February 2022 | Accepted: 7 March 2022 | Published: 7 July 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Smokers are known to have a higher risk of erectile dysfunction. We examined how daily consumption of low-dose tadalafil affected erectile function and circulation in smokers and assessed the medication safety. Methods: Men aged over 20 years with current smoking status were selected to complete four weeks of treatment with 5 mg tadalafil daily. Erectile function was measured using the International Index of Erectile Function (IIEF), and additional tests included measuring various serum parameters, electrocardiogram, and nail capillary blood flow. Results: The IIEF scores, capillary blood flow, and serum liver function enzyme levels significantly improved. There were no reported adverse side effects. Conclusions: Smokers who were administered 5 mg tadalafil daily for four weeks had improved International Index of Erectile Function scores, dilated capillary vessels, and improved blood liver function enzyme levels; proving not only safety of usage and its effectiveness but also possible features that can indicate usages of the drug in other purposes.

erectile dysfunction
liver function
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