IMR Press / JOMH / Volume 18 / Issue 6 / DOI: 10.31083/j.jomh1806130
Open Access Case Report
Post-orgasmic illness syndrome accompanied with testosterone deficiency: a case report
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1 Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730 Beijing, China
*Correspondence: (Hongjun Li)
J. Mens. Health 2022, 18(6), 130;
Submitted: 6 November 2021 | Accepted: 9 December 2021 | Published: 27 May 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Post-orgasmic illness syndrome (POIS) is a rare disease that affects the quality of life of patients. Here, we report a case of a 27-year-old man who visited our clinic and presented with physical fatigue, muscle weakness, emotional irritability, memory difficulties, lack of attention, and flu-like state after ejaculation. The patient was diagnosed with POIS accompanied by testosterone deficiency (TD) and treated with antiallergic therapy combined with testosterone supplementation therapy (TST) and selective serotonin reuptake inhibitor (SSRI). After 3 months of medication, the patient’s POIS symptoms, testosterone levels, and relevant questionnaire scores significantly improved. Antiallergic therapy combined with TST and SSRI treatment can effectively treat patients with POIS accompanied by TD.

Post-orgasmic illness syndrome
Antiallergic therapy
Testosterone deficiency
Testosterone supplementation therapy
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