IMR Press / JOMH / Volume 18 / Issue 5 / DOI: 10.31083/j.jomh1805107
Open Access Review
Changes in the treatment landscape for metastatic urothelial cancer: current therapy and future directions
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1 Department of Internal Medicine, Chungnam National University Hospital, 35015 Daejeon, Republic of Korea
*Correspondence: (Hyo Jin Lee)
J. Mens. Health 2022, 18(5), 107;
Submitted: 1 November 2021 | Accepted: 20 December 2021 | Published: 6 May 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Despite the development of several new drugs, cisplatin-containing chemotherapy remains the standard frontline option for advanced urothelial carcinoma (UC). Since the cisplatin-based regimen became the standard therapy for metastatic UC, there have been few advances in chemotherapy, until recently. A better understanding of molecular pathobiology of UC and advances in cancer immunology have led to a sharp increase in clinical trials for metastatic UC with the rapidly changing systemic treatment for this disease. This review summarizes current chemotherapy and immunotherapy for metastatic UC, as well as novel agents and ongoing trials.

urothelial carcinoma
cytotoxic chemotherapy
targeted agent
antibody-drug conjugate
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