IMR Press / JOMH / Volume 18 / Issue 4 / DOI: 10.31083/j.jomh1804090
Open Access Case Report
Prostatic signet-ring adenocarcinoma: A case report
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1 Department of Pathology and Forensic Medicine, Faculty of Medicine, Al-Balqa Applied University, 19117 Al-Salt, Jordan
2 Department of Pathology, Al Hussein Salt Hospital, Ministry of Health, 19117 Al-Salt, Jordan
3 Department of Urology, Al-Hussein Salt Hospital, Ministry of Health, 19117 Al-Salt, Jordan
*Correspondence: (Ali Al Khader)
J. Mens. Health 2022, 18(4), 90;
Submitted: 26 August 2021 | Accepted: 11 October 2021 | Published: 7 April 2022
(This article belongs to the Special Issue Therapy and prognosis of metastatic prostate cancer)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Prostatic signet-ring adenocarcinoma is a rare histological variant of prostate cancer. The tumor is characterized by an aggressive clinical course. Methods: Herein we present the case of a 78-year-old man with obstructive urinary symptoms and elevated serum prostate specific antigen. Transurethral resection of the prostate was performed. Results: Histologically, a tumor that was mainly composed of signet ring cells was identified. The tumor cells were positive for alcian blue special stain. Another Gleason 4 adenocarcinoma component was identified. The patient received hormonal therapy. A favorable response was documented at 8 months of follow up. Conclusions: Ruling out another primary site of origin, such as the gastrointestinal tract, is mandatory, and a more aggressive management plan should be put in mind.

Signet ring cell
Fig. 1.
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