IMR Press / JOMH / Volume 18 / Issue 1 / DOI: 10.31083/jomh.2021.071
Open Access Original Research
Nitric oxide mediated effects of nebivolol on erectile function in rats with heart failure
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1 Department of Pharmacology, Hamidiye Pharmacy Faculty, Universityof Health Sciences, 34668 Istanbul, Turkey
2 Department of Pathology, Haydarpasa Numune Training and ResearchHospital, University of Health Sciences, 34668 Istanbul, Turkey
3 Department of Pharmacology, School of Pharmacy, Istanbul MedipolUniversity, 34815 Istanbul, Turkey
J. Mens. Health 2022, 18(1), 9; https://doi.org/10.31083/jomh.2021.071
Submitted: 9 February 2021 | Accepted: 19 March 2021 | Published: 17 January 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background and objective: Heart failure (HF) is a common complication of cardiovascular disease, which leads to functional cardiac abnormalities. Beta-blockers are commonly used to reduce mortality in HF patients; however, they are associated with an increased risk of erectile dysfunction (ED). Nebivolol is a third-generation beta-blocker with also having a Nitric oxide (NO) releasing effect. NO plays a key role in penile erection. The aim of this study was to investigate the NO-mediated effects of nebivolol on ED in HF. Material and methods: Twenty-four weeks old rats were divided into three groups: sham-operated control (SC), HF-induced control (HFC), and nebivolol-treated (HFNEB). HF was induced by the ligation of the left anterior descending coronary artery. Eight weeks after the ligation, functional, hemodynamic, biologic, and histologic studies were conducted to assess NO-mediated effects of nebivolol. Results: HF rats displayed impaired erectile function represented by decreased intracavernosal/mean arterial pressure ratio (ICP/MAP). Increased nitrosative damage/decreased antioxidant capacity was consistent with decreased endothelial NOS (eNOS) and increased inducible NOS (iNOS) and neuronal NOS (nNOS) immunoreactivity in this group. Nebivolol treated animals were characterized by improved functional capacity, increased antioxidant and decreased oxidant capacity. Prevention of eNOS and an increase in nNOS immunoreactivity was also significant in this group. Conclusion: Our study showed the positive effects of nebivolol on erectile function in HF. NO-mediated mechanisms behind this effect can be summarized as eNOS mediated dilation of the cavernous body and nNOS mediated smooth muscle relaxation. To the best of our knowledge, this study is the first in the literature to discuss all three NOS isoforms in order to explain the NO-mediated effects of nebivolol in ED.

Keywords
Erectile dysfunction
Nitric oxide
Heart failure
Nitric oxide synthase
Nebivolol
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