IMR Press / JOMH / Volume 14 / Issue 2 / DOI: 10.22374/1875-6859.14.2.3

Journal of Men’s Health (JOMH) is published by IMR Press from Volume 17 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Dougmar Publishing Group.

Original Research

Effects of Resistance Exercise Intensity on Cytokine and Chemokine Gene Expression in Atopic Dermatitis Mouse Model

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1 Assistant Professor, Department of Physical Education, Daegu Catholic University, Gyeongsan, Republic of Korea
2 Associate Professor, Sports and Health Care Major, College of Humanities and Arts, Korea National University of Transportation, Chungju-si, Republic of Korea

*Author to whom correspondence should be addressed.

J. Mens. Health 2018, 14(2), 14–21;
Submitted: 15 December 2017 | Accepted: 3 April 2018 | Published: 13 April 2018

Background and Objective

Although the evidence is unclear, literature indicates that resistance exercise reduces inflammation in colorectal disease. The purpose of this study was to identify the effects of colon tissue on cytokine and chemokine gene expression with changes in resistance exercise intensity.

Material and Methods

We divided male BABL/c mice into 6 groups (each group n=10, total=60) (control group: CON, low resistance exercise group: EX_L, high resistance exercise group: EX_H, atopic dermatitis group: AD, atopic dermatitis+low resistance exercise group: AD+EX_L, atopic dermatitis+high resistance exercise group: AD+EX_H) and subjected them to ladder climbing resistance exercise for 4 weeks. After 24 h of each exercise schedule, a real-time polymerase chain reaction was performed to determine mRNA expression of interleukin-6 (IL-6) and chemokine ligand 20 (CCL20).


The AD group showed significantly higher mRNA expression of IL-6 and CCL20 compared with the CON, EX_L, EX_H, AD+EX_L, and AD+EX_H groups (p<0.05).


In conclusion, both high and low resistance exercise effectively decreases the concentration of IL-6 and CCL20 in mice with and without AD.

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