IMR Press / JMCM / Special Issues / 1617109443540

The interactions of cellular and molecuar pathways in developing malignancies

Submission deadline: 31 October 2021
Special Issue Editors
Elahe Khodadi, MSc
Research center of thalassemia & hemoglobinopathy, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Interests: Bone marrow niche; Molecular pathways; Epigenetics; Cancer biology
Special Issue Information

Dear Colleagues,
The bone marrow (BM) microenvironment is composed of Hematopoietic stem cells (HSCs), mesenchymal stromal cells (MSCs), vascular cells, and osteolineage cells. Endosteal and vascular niches as two main niches in BM have important interaction and communications. BM niche controls the HSCs by the production and secretion of different cytokines and extracellular matrix (ECM) molecules. The genetic and epigenetic events are needed in a cell in developing a malignancy, but recent studies have shown that a model for oncogenesis in the niche that develops the pathogenesis process in the malignancies. The microenvironment pathways can result in the development and clonal expansion of malignant cells. In this issue, we try to discuss the cellular and molecular pathways involved in the BM niche to develop different malignancies. Targeting the cells and molecular pathways in the BM niche involved in the development of hematological malignancies can suggest a better diagnosis and treatment of these diseases in the future.

Dr. Elahe Khodadi

Guest Editor

Keywords
Bone marrow niche
Cellular
Molecular
Malignancies
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at https://jour.ipublishment.com/imr/access/login by registering and logging in to this website. Once you are registered, click here to start your submission Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 500 USD. Submitted papers should be well formatted and use good English.

Back to top