The bone marrow (BM) microenvironment is composed of Hematopoietic stem cells (HSCs), mesenchymal stromal cells (MSCs), vascular cells, and osteolineage cells. Endosteal and vascular niches as two main niches in BM have important interaction and communications. BM niche controls the HSCs by the production and secretion of different cytokines and extracellular matrix (ECM) molecules. The genetic and epigenetic events are needed in a cell in developing a malignancy, but recent studies have shown that a model for oncogenesis in the niche that develops the pathogenesis process in the malignancies. The microenvironment pathways can result in the development and clonal expansion of malignant cells. In this issue, we try to discuss the cellular and molecular pathways involved in the BM niche to develop different malignancies. Targeting the cells and molecular pathways in the BM niche involved in the development of hematological malignancies can suggest a better diagnosis and treatment of these diseases in the future.
Dr. Elahe Khodadi
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