IMR Press / JMCM / Volume 5 / Issue 1 / DOI: 10.31083/j.jmcm0501002
Open Access Case Report
Double Hit Lymphoma Mimicking B Cell Precursor Phenotype Burkitt Lymphoma/Leukemia in an Elderly
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1 Division of Hematology, Uji-Tokushukai Medical Center, 611-0021 Uji, Japan
2 Department of Diagnostic Pathology, Uji-Tokushukai Medical Center, 611-0021 Uji, Japan
3 Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 606-8391 Kyoto, Japan
4 Department of Laboratory Medicine, Uji-Tokushukai Medical Center, 611-0021 Uji, Japan
*Correspondence: (Shinsaku Imashuku)
Academic Editor: Giuseppe Murdaca
J. Mol. Clin. Med. 2022, 5(1), 2;
Submitted: 3 June 2022 | Revised: 21 July 2022 | Accepted: 3 August 2022 | Published: 12 August 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: The differential diagnosis of Burkitt lymphoma/leukemia (BL) and the double or triple hit lymphomas remains often problematic in terms of immunophenotyping in association with MYC gene analysis. In the past, BL-like B-cell malignancy with B-cell precursor phenotype (BCP-ALL) was described. Case Report: We report here an 84-year-old male with massive ascites without superficial lymphadenopathy. Abdominal paracentesis revealed chylous (non-bloody) ascites consisting of mostly abnormal BL-like blasts showing CD20-negative BCP phenotype. However, molecular study indicated no MYC/IGH, but probable involvements of MYC/IGL and BCL6/IGH translocations, which were confirmed by FISH studies. The patient was diagnosed as double hit lymphoma mimicking BCP-ALL.

double hit lymphoma
burkitt lymphoma
terminal deoxynucleotidyl transferase
Fig. 1.
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