Mature cystic ovarian teratomas are ovarian tumors that are most common in reproductive age women. MCTs are benign germ cell tumors that arise from totipotent germ cells in the ovary. Endometriosis is also a common gynecologic disease affecting reproductive age women. Endometriosis is a progressive and chronic disease associated with inflammation, chronic pelvic pain, and infertility. However, the pathophysiology, symptoms, diagnosis, and management of each disease are well known, but there is little information on the simultaneous occurrence of these two diseases. Therefore, the epidemiology, clinical symptoms, imaging, management, and the risk of malignant transformation of the coexistence of MCTs and endometriosis are discussed herein. PubMed and any reports of individuals with both MCTs and endometriosis were searched for all articles written in the English-language medical literature until May 2020. This review indicates that diagnosis and treatment of the coexistence of MCTs and endometriosis are more complicated when two diseases coexist than when only one disease exists. In conclusion, this comorbid conditions may not be as rare as it was previously thought. To understand and treat this complex condition, more studies are essential.
Mature cystic teratomas (MCTs), also known as dermoid cysts, are the most common benign ovarian tumors in women of reproductive age. MCTs are germ cell tumors that originate from totipotent germ cells which develop into fully differentiated endodermal, mesodermal, and ectodermal tissue [1]. Most of MCTs have few symptoms even if they are quite larger. They are often found incidentally on routine physical examination or imaging or when surgery is performed for other causes. Therefore, surgery is often performed in an emergency in cases with symptoms such as acute abdominal pain due to torsion.
Endometriosis is a common and debilitating gynecologic disorder which affects mostly reproductive age women. It is an estrogen-dependent disease characterized by the presence of endometrial glands and stroma outside the uterine cavity, often associated with inflammation, chronic pain, and infertility [2]. To relieve symptoms such as pain or to improve fertility, surgery is performed.
Although MCTs and endometriosis are benign ovarian tumors encountered frequently in women of childbearing age, the coexistence of these two diseases has been reported in only a few case reports so far. However, a few studies describing the coexistence MCTs and endometriosis directly or indirectly have been published recently [3, 4, 5, 6]. Therefore, the author intended to gather and organize available knowledge to help find the clinical implications of this rare and challenging condition and establish a framework for diagnosis and treatment.
PubMed and any reports of individuals harboring both MCTs and endometriosis were searched for all articles written in the English-language medical literature to May 2020 using the keywords ‘coexistence’, ‘endometriosis’, and ‘teratoma’. All reports were carefully assessed and their references were also reviewed.
MCTs are the most common type of germ cell tumors accounting for 15% of all ovarian tumors and 43%-70% of benign ovarian tumors [7]. They comprise approximately 70% of benign ovarian tumors in women under 30 years of age and 50% of pediatric tumors [8]. However, most MCTs are asymptomatic, so the reported prevalence may have been reported to be lower than they actually are. Studies on the location of MCTs are controversial. Some studies reported conflicting results [9], but the results that MCTs occur more on the right side are dominant [10, 11, 12]. In addition, they can be located at the midline and in paraxial regions of the body and unusual locations, including lungs or ilea [13]. In approximately 10-15% of cases, they are on both sides [14].
Most of MCTs are asymptomatic. They are discovered incidentally by routine physical examination, radiologic examinations, or during surgery performed for other pathologies [6]. However, they can cause acute complications including ovarian torsion, infection, rupture, or malignant transformation [15].
Endometriosis is a common gynecologic condition characterized by the presence of endometrial glands and stroma outside the uterine cavity, which affects approximately 7-10% of women in the reproductive age [16]. However, among infertile women, endometriosis increases up to 20-50% and in women with pelvic pain to 30-80% [17]. Endometrioma is the cystic tumor within the ovary with ectopic endometrium tissue lining and is found to be in 17%-44% of women with endometriosis [18]. Ovarian endometriosis has been reported to affect 20% of women with endometriosis [19]. Endometriosis occurs more frequently on the left side than the right side [20, 21, 22]. The hypothesis of this claim has been explained because of the barrier role of the sigmoid colon [20]. Bilateral ovarian endometriosis has been reported to affect 19-28% of cases [23]. Endometriosis has been reported to involve commonly uterus, fallopian tubes, intestine, and uterosacral ligaments. It has been reported to involve rarely the vagina, urinary bladder, ureter, lungs, gastrointestinal tract, bones, and central nervous system [17].
Symptoms of endometriosis range from asymptomatic to extreme pain, enough to interfere with daily life. The main symptom is pelvic pain, but other symptoms include dysmenorrhea, deep dyspareunia, and dyschezia [24]. In addition, 20% of women with endometriosis suffer from subfertility [25].
So far, four studies have mentioned the prevalence of the coexistence of MCTs and endometriosis. Matalliotaki et al. evaluated the association between benign gynecological tumors and endometriosis in 1,000 women with endometriosis [3]. They showed that MCTs were found in 1.5% of women with endometriosis. Thereafter, Matalliotakis et al. evaluated the association between ovarian dermoid cyst (teratoma) and endometrioma [4]. They showed that the coexistence of ovarian teratoma with endometriosis detected in 4.6% (8/172) of women and with endometrioma in 2.9% (5/172). They found the simultaneous coexistence of 13 cases with endometriosis or endometrioma. They also found 6 patients with dermoid cyst and endometriosis or endometrioma in the same ovary. In a study of 80 patients with MCTs, Kurt et al., tried to find out their association with fertility and to detect the rate of malignant degeneration [5]. They found that MCT was encountered in 9 patients during examination for infertility, 6 of whom had accompanying endometriosis. According to their research, the coexistence of MCTs and endometriosis was detected in 7.5% (6/80) of women. Recently, Heesuk Chae evaluated the incidence of endometriosis in women with mature cystic ovarian teratoma and analyzed the clinicopathologic features of this occurrence [6]. According to the study, a total of 71 patients were included, of which 55 (77.46%) had teratoma and 16 (22.54%) harbored the coexistence of endometriosis and MCTs.
No | Reference | Age (yrs) | Number of cases (n) | Presenting symptom | Side | Size of cyst (cm) | Intraoperative findings | Treatment |
1 | Caruso et al, 1997 [26] | 28 | 1 | Abdominal pain | Lt | 5 | cystectomy | |
2 | Frederick et al, 2003 [27] | 27 | 1 | Dysmenorrhea | Rt (6), Lt (4) | Severe adhesion | cystectomy | |
3 | van der Merwe et al, 2010 [28] | 30 | 1 | Abdominal distension | Rt | 40 | Severe adhesion | oophorectomy |
4 | Sindilar et al, 2011 [29] | 30 | 1 | Abdominal pain | Lt | 6 | cystectomy | |
5 | Chen et al, 2011 [30] | 35 | 1 | Abdominal pain | Rt | 7 | Severe adhesion | cystectomy |
6 | Prorocic et al, 2012 [31] | 33 | 1 | Dysmenorrhea | Lt | 5.5 | Adhesion | cystectomy |
7 | Chae et al, 2015 [32] | 28 | 1 | Lt | cystectomy | |||
8 | Taylor et al, 2015 [33] | 33 | 1 | Incidentally | Rt | 9 | Adhesion | oophorectomy |
9 | Wagner et al, 2015 [34] | 34 | 1 | Dysmenorrhrea | Both | cystectomy | ||
10 | Hwang et al, 2017 [35] | 22 | 1 | Flank pain | Lt | 3 | cystectomy | |
11 | Darouichi et al, 2017 [13] | 33 | 1 | Pelvic pain | Lt | 8 | cystectomy | |
12 | Kiyak et al, 2018 [36] | 25 | Case 1 | Pelvic pain, dysmenorrhea | Lt | 13 | Severe adhesion | cystectomy |
22 | Case 2 | Dysmenorrhea | Rt | 6 | cystectomy | |||
13 | Rokhgireh et al, 2019 [37] | 31 | 1 | Dysmenorrhea | Rt: teratoma Lt: endometrioma | Rt (9) Lt | Adhesion | cystectomy |
Based on the case reports and a study about the coexistence of MCTs and
endometriosis, clinical findings of this rare condition were reviewed. Thirteen
case reports describing the coexistence of MCTs and endometriosis were found, for
a total of 14 individuals with pathological features of both MCTs and
endometriosis (Table 1). The size of the cyst is represented by the largest
diameter. The location of the cyst was only marked with lesions of the
coexistence of MCTs and endometriosis. For bilaterally, the size is noted in
parentheses at each location. In case 2, teratomas were in found in both ovaries
and endometriosis was a peritoneal type. In case 13, teratoma was in the right
ovary and endometriosis was in the left ovary. The mean age of 14 patients of the
case reports was 29.4 years (range 22-35 years). The average age of patients with
this rare condition was 27.38
Table 1 shows that 53.8% (7/11) of the cases were on the left side, whereas 36.4% (4/11) were on the right. Case 2 was excluded because of peritoneal endometriotic lesions whereas case 9 was excluded because there was no detailed mention about the location of the cyst. Case 13 was also excluded because endometriosis occurred on the left and teratoma on the right. There is a hypothesis as to why the majority of endometriomas are located in the left ovary. The hypothesis is that the origin of endometriosis is regurgitated endometrial cells and furthermore the presence of the sigmoid colon may be related to decrease fluid movement in the left side of the pelvis [22]. In those teratomas observed frequently in the right side, Vercellini et al. suggested a different pathogenesis of the two entities [38].
To summarize the above, the coexistence of MCTs and endometriosis occurs frequently in women of reproductive age. The most common presenting symptom in patients with this rare condition may be dysmenorrhea and the location has not yet been confirmed.
Ultrasonography has been the 1
The most commonly used imaging modalities to diagnose endometriosis are transvaginal ultrasonography and MRI. Transvaginal ultrasonography also has been the first-line imaging examination. Mais et al., showed that using a characteristic ultrasonographic finding (round-shaped homogenous hypoechoic “tissue” of low-level echoes within the ovary), transvaginal ultrasonography has an efficiency of 88% in differentiating endometriomas from other ovarian masses with a specificity of 90% [47]. MRI for endometriosis is usually performed when the ultrasonographic findings are inconclusive or if malignancy is suspected. Hottat et al. studied the accuracy of MRI imaging in the preoperative assessment of endometriosis and then showed that sensitivity and specificity were 96.3%, 100%, respectively [48]. CT is not effective in diagnosing endometriosis because it cannot see the pelvic organs well, but it is useful in cases such as ureteral involvement [49].
There is little information regarding the diagnosis of the coexistence of MCTs and endometriosis. Therefore, considering only the patients mentioned in Table 1, nearly all patients, excluding cases 7, 11 and 12, were not diagnosed before surgery. MRI was performed in 4 cases, 1 case was suspected of malignancy, and the rest diagnosed this rare condition (data not shown). Several methods have been suggested as a way to distinguish teratoma from endometriosis, and they are as follows: chemical-shift artifact in the frequency-encoding direction [50], phase-shift gradient-echo imaging [51], and sequences with frequency-selective fat saturation technique [42]. This rare disease such as the coexistence of MCTs and endometriosis presents challenges not only to clinicians but also to radiologists. In the end, getting used to the imaging features of this rare condition will help the differential diagnosis.
Because benign ovarian cysts such as MCTs occur most commonly in the reproductive age women, it has been accepted as the standard strategy that cystectomy is performed to preserve healthy ovarian tissue as much as possible. In women at perimenopause or postmenopause, adnexectomy or oophorectomy is the method of choice. Laparoscopy has become the gold standard technique in the management of benign ovarian tumors. Compared with laparotomy, laparoscopic surgery has many advantages such as shorter recovery time, cosmetic benefits, and less postoperative pain [8, 52]. According to studies comparing laparoscopy and laparotomy, laparoscopy has a greater risk of cyst rupture and spillage of the cyst content than laparotomy [53, 54]. Thus, laparotomy will be feasible if the cyst is large or exists bilaterally or if malignancy is suspected.
Laparoscopy has become the gold standard for the management of endometriosis. The European Society of Human Reproduction and Embryology guidelines recommend that surgical approach should be performed in women complaining of pain associated with endometriosis or in women with endometrioma greater than 3 cm [55]. Surgery should be performed to remove visible lesions and restore the normal anatomic structure. However, in the cases of advanced endometriosis, the possibility of conversion to laparotomy or oophorectomy due to severe adhesions should be discussed before operation.
For MCTs, spillage of the contents due to intraoperative rupture of teratoma has
been reported to be associated with chemical peritonitis and adhesion formation
[8, 56]. Post-operative adhesions due to spillage of the contents may result in
problems such as infertility [56]. The risk of intra-operative spillage is
reported to be in 40-50% of cases during laparoscopic cystectomy, compared to
10-15% during laparotomy with cystectomy [57, 58, 59]. Caspi et al. suggested
that because the mean growth rate of MCTs in premenopausal women is 1.8 mm/year,
premenopausal women with MCTs of
The coexistence of MCTs and endometriosis can further complicate the problem of
treatment. In Table 1, 7 out of 14 (50%) cases showed adhesions during surgery,
4 of which exhibited severe adhesions. Chae H. [6] showed that in patients with
coexistence of MCTs and endometriosis when compared with patients harboring MCTs
alone, the size of the cyst was larger and the operation time was longer. In
addition, advanced-stage endometrisis (stage III or IV) was present in 8 out of
16 (50%) patients with this rare concurrence. In order to prevent spillage of
the contents of MCTs, a method of removing cysts in an endobag has been proposed
[67]. However, it is difficult to apply this method in cases with large cyst or
with adhesion. Finally, the probability of spillage of the cyst content during
laparoscopic cystectomy is much higher than in the cases of only MCTs. In
addition, the researcher found that damage to ovarian reserve after surgery was
also greater in patients with MCTs alone [6]. Kurt et al. reported that MCTs can
be present concurrent with endometriomas, but infertility is prominent in
patients with concurrent endometriosis [5]. According to Shi et al. endometriotic
cells of endometriomas synthesize and secret transforming growth factor beta 1
(TGF-
MCTs are known as benign tumors with a high recurrence rate. Anteby et al.,
reported that women with bilateral or multiple dermoid cysts are more likely to
recur later [69]. Lagerbe et al. showed that ovarian cystectomy performed by
laparoscopy when compared to laparotomy, is associated with a significantly
higher risk of recurrence [70]. Harada et al. reported a long-term recurrence
rate of 4.2% after surgical excision of MCTs. In this respect, patients with
young age (
Twenty-seven percent of patients are readmitted to the hospital for additional surgery, 12% of which undergo hysterectomy [72]. Because there is no data on the recurrence of coexistence of MCTs and endometriosis, this point cannot be addressed at the moment, however it can be inferred that the probability of recurrence after surgery is very high in this rare concurrence because both endometriosis and MCTs recur easily.
Malignant transformation of MCTs was found in 1%-2% of MCTs [73]. More than 80% of malignant transformation are squamous cell carcinoma, the rest are carcinoid tumors or adenocarcinomas [74]. Malignancy occurs in older women with mean age of 45-60 [75]. Kikkawa et al., showed that a tumor larger than 9 cm in dimension was 86% more prone for malignant transformation in their series [76]. Santos et al. showed that the average diameter was 14.2 cm, indicating that larger tumors correlate with an increased risk of malignant transformation [73]. Many studies have attempted to reveal the relationship between endometriosis and ovarian cancer. Ovarian cancer in women with endometriosis is found to be with an occurrence rate of 0.3-1.6% [77, 78, 79]. Brinton et al. showed that the risk of ovarian cancer was particularly increased in patients with a long-standing history of ovarian endometriosis [80]. A cohort study showed that ovarian cancer associated with endometriosis occurs in two histologic subtypes: endometrioid and clear cell [81]. Gadducci et al. reported that the malignant transformation of ovarian endometriosis occurs in 0.7-2.5% of patients [82].
MCTs, the most common form of malignant transformation of MCTs (squamous cell carcinoma), endometriosis, and two histologic subtypes of malignant transformation of endometriosis (clear cell and endometrioid) are reviewed in the literature in order to find cases with malignant transformation of the coexistence of MCTs and endometriosis. Primary squamous cell carcinoma arising from endometriosis of ovary cases were excluded, and cases of malignant transformation from teratoma (endometrioid carcinoma or clear cell carcinoma) were also excluded. A total of three cases were found, and a case report was written in English [83]. The rest of cases were reported in Japanese and hence excluded [84, 85]. Shimura et al. [83] reported a 71-year-old patient who underwent surgery with a tumor up to 40 cm in the right ovary. The pathologic diagnosis was MCT, endometriotic cyst, clear cell carcinoma, clear cell adenofibroma, and clear cell borderline tumor. However, even in this case, the author suggested that clear cell adenofibroma, not endometriosis, had developed into clear cell carcinoma, so it cannot be regarded as malignant transformation of the coexistence of MCTs and endometriosis.
MCTs and endometriosis are the most common benign diseases in reproductive age women, but little research has been conducted on the simultaneous occurrence of these two diseases. Therefore, unlike MCTs or endometriosis alone, diagnosis and treatment of endometriosis can be a challenge for clinicians and radiologists. However, judging from the above evidence, if women diagnosed with MCTs complain of dysmenorrhea, it is important to be aware of the possibility of coexisting endometriosis. Also, if the cyst size is large or the menstrual cramps are getting worse, it may be more appropriate to make an accurate diagnosis and treatment plan through a surgical approach rather than conservative management. However, further research on the coexistence of MCTs and endometriosis is warranted because knowing the incidence of the disease, risk factors and an understanding of the pathophysiology of this rare condition, will serve as a guide in establishing a proper treatment protocol.
We would like to express my gratitude to all those who helped me during the writing of this manuscript.
The author declares no conflicts of interest.