IMR Press / JIN / Special Issues / tau_functions_brain_disorders

Tau Functions and Dysfunctions in Brain Disorders

Submission deadline: 21 April 2023
Special Issue Editor
  • Viswanath Das, PhD
    Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic
    Interests: neurodegeneration; translational disease models; drug discovery
Special Issue Information

Dear Colleagues,

Tau is a microtubule-associated protein that is abundantly expressed in neurons. It plays a critical role in regulating microtubule functions, thereby affecting diverse biological processes in the brain. Tau aggregation and its progression are seminal events in tauopathies, a group of neurodegenerative diseases characterised by intracellular aggregates of hyperphosphorylated tau. Mutations and hyperphosphorylation of tau, particularly in and around the microtubule-binding domain, cause misfolding and aggregation under pathological conditions. Misfolded tau aggregates are known to spread intraneuronally and induce pathological changes in native tau in neighbouring cells, thus propagating tau pathology. Although the primary function of tau in the brain is not yet clear, our understanding of the pathological mechanisms through which it contributes to neurodegenerative diseases has become clearer over the years. However, despite these advances there is still considerable progress to be made in translating this knowledge into effective therapeutic strategies. The aim of this special issue is therefore to gather excellent and focused research studies on the diverse roles of tau in neurodegenerative diseases, and on potential new treatment approaches for the mitigation of tau dysfunction.

Dr. Viswanath Das

Guest Editor

neurodegenerative diseases
neurofibrillary tangles
microtubule-associated proteins
protein kinases
small molecules
tau propagation
therapeutic strategies
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.

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