IMR Press / JIN / Special Issues / neuroplasticity

Neurophysiology and Genetics of Brain Plasticity in Cerebrovascular Diseases

Submission deadline: 20 March 2024
Special Issue Editors
  • Aurel Popa-Wagner, PhD
    Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, University of Duisburg—Essen, Essen, Germany
    Interests: aging; cerebrovascular diseases; brain plasticity; gene expression.; therapies
    Special Issues and Topics in IMR Press journals
  • Bogdan Catalin, PhD
    Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, Craiova, Romania
    Interests: microglia; brain; cerebrovascular diseases; brain plasticity; imaging
Special Issue Information

Dear Colleagues,

How aging and stress affect neural plasticity and depression 
Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of neuronal adaptation, is affected in cerebrovascular conditions that include traumatic brain injury and brain ischemia. Age-related changes in neural plasticity play a significant role in the onset and development of cerebrovascular diseases. Despite the initial hope that cell-based therapies might stimulate restorative processes in the degenerative brain, we now recognized that aging processes may promote an unfavorable environment for such treatments. Alternatively, in the last several years, many groups have focused on exploiting brain plasticity, which is preserved to some extent even in old brains, to enhance the brain’s endogenous repair mechanisms after insults such as traumatic brain injury or cerebral ischemia.

Virtually all drug interventions that have been successful in animal models have failed to translate successfully to the clinical setting. The failure to consider the aging-brain’s plasticity and complexity, and the heterogeneity of human diseases and co-morbidities, may have rendered neuroprotective drugs less effective in clinical practice.

The main opponent of brain plasticity in the aged brain is neuroinflammation. It is becoming evident that with increasing age, the brain’s subtle but continuous neuroinflammation can provide the basis for disorders such as cerebral small vessel disease (cSVD) and consequent dementia. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity hypertension, diabetes, and atherosclerosis, are increasingly understood to act as “silent contributors” to neuroinflammation—not only establishing the condition as a central pathophysiological mechanism, but also constantly fueling it. Acute neuroinflammation, often in the context of traumatic or ischemic CNS lesions, aggravates the acute damage and can lead to a number of pathological illnesses, such as depression, post-stroke dementia, and potentially, neurodegeneration. All of those sequelae impair recovery, and most of them provide the basis for further cerebrovascular events; thus, a vicious cycle develops. Recent advances in signaling pathways can potentially protect cells as well as provide treatment options for the maintenance of brain capillaries, in order to prevent diseases associated with brain-vasculature remodeling in response to aging and associated comorbidities.

This special issue of Neural Plasticity will provide up-to-date information on molecular, cellular, and behavioral events associated with neurodegenerative diseases and new therapeutic options.

1)    Aging, comorbidities, and risk of neurodegenerative diseases and stroke
2)    Vascular risk factors for neurodegenerative diseases
3)    Aging and vascular risk factors for cognitive decline and dementia
4)    Aging and metabolic risk factors for hemorrhagic stroke
5)    Brain plasticity and aging
6)    Brain plasticity and epilepsy
7)    Brain plasticity and neurobehavioral recuperation after cerebral ischemia

Aurel Popa-Wagner and Bogdan Catalin
Guest Editors

brain plasticity
cerebrovascular diseases
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.

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