Epilepsy is a brain disorder occurring in at least 1% of the population. It is characterized by neuronal hyperexcitability, alterations in synaptic function, and often neuronal death. Chronic neuroinflammation is thought to contribute to the development of epilepsy. Epileptic seizures cause the activation of microglia and astrocytes, which subsequently induces liberation by the activated glial cells of pro-inflammatory cytokines such as IL-1β, IL-6, IL-2, IL-8 and TNFα. Pro-inflammatory cytokines are the major non-neuronal contribution to seizure as a consequence of the imbalance between inhibition and excitation. It is important to note that neuroinflammatory processes can be acquired from systemic inflammation and that entry of peripheral immune cells via disruption of the Blood Brain Barrier (BBB) is known to be epileptogenic. Immune cells in the blood such as macrophages and monocytes are highly activated after seizures. Importantly, inhibiting the chemotaxis of leukocytes across the BBB reduces the severity of seizures.
This Research Topic welcomes papers that study or discuss inflammatory processes in epilepsy, with a particular focus on systemic inflammation and the role of BBB in inflammatory processes in the human and rodent. The aim is to make researchers aware of the need to integrate systemic inflammatory processes in neuropathology. In this topic we will focus particularly on articles that describe:
-Impact of inflammatory processes on BBB
-Blood leucocytes infiltration in parenchyma
-Differences in inflammatory processes according to the epileptic syndrome
Role of BBB in inflammatory processes
Dr. Mélanie Morin-Brureau and Dr. Giampaolo Millior
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted manuscripts should be well formatted in good English.