IMR Press / JIN / Special Issues / deep_brain_stimulation_depression

Medial Forebrain Bundle Deep Brain Stimulation for Major Depression—Preclinical and Clinical Research

Submission deadline: 31 May 2023
Special Issue Editors
  • Marco Reisert, PhD
    Department of Stereotactic and Functional Neurosurgery, Medical Center of the University of Freiburg, Freiburg, Germany; Medical Faculty of the University of Freiburg, Freiburg im Breisgau, Germany
    Interests: deep brain stimulation; medial forebrain bundle; chronic depression
  • Volker A. Coenen, MD
    Department of Stereotactic and Functional Neurosurgery, Medical Center of the University of Freiburg, Freiburg, Germany; Medical Faculty of the University of Freiburg, Freiburg im Breisgau, Germany; Center for Deep Brain Stimulation, University of Freiburg, Freiburg im Breisgau, Germany
    Interests: extension of indications for deep brain stimulation in the psychiatric spectrum; imaging-assisted deep brain stimulation; animal experimental approaches to understanding the mode of action of deep brain stimulation
Special Issue Information

Dear Colleagues,

The medial forebrain bundle (MFB) is a key structure for reward and motivation and has been linked to affective disorders including major depression (MD) and obsessive-compulsive disorder (OCD). Clinical studies of deep brain stimulation (DBS) that modulate the MFB system by stimulating the superolateral branch of the medial forebrain bundle (slMFB) have shown promising antidepressant efficacy. Moreover, the slMFB is an emerging target structure for OCD. Initial results have been replicated by international scientific groups with equally promising efficacy. The slMFB structure and its definition, function and nomenclature are currently a focus of scientific debate. Recent non-human primate tract tracing has confirmed the anatomy and function of this structure. Preclinical work using optogenetic manipulations and fiber-photometry read-outs has investigated dopaminergic transmission as the mechanism of MFB DBS. Clinical positron emission tomography work has discovered metabolic patterns in MD that are altered by DBS. A decade after the first clinical work on this target structure, there is now a clear need to gather the current neuroscientific evidence.

For this special issue, we invite Neurologists, Neuroscientists, Neurosurgeons and Psychiatrists to submit their work related to MFB DBS. Clinical work on MD, OCD and other indications are equally welcome, as well as preclinical work on the mechanisms of MFB DBS that help to understand clinical efficacy.

If you are uncertain whether your work falls within the remit of this special issue, please do not hesitate to contact and discuss directly with the editors.

We look forward to receiving your submissions to help make this special issue a success!

Prof. Dr. Marco Reisert and Prof. Dr. Volker A. Coenen

Guest Editors

common tract
deep brain stimulation
major depression
midbrain target
reward system
superolateral medial forebrain bundle (slMFB)
tract tracing
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.

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