Neuroinflammation in Cerebral Injury

Dear Colleagues,

Neuroinflammation is a major component of central nervous system injuries and neurological diseases, including stroke. The activation of immune cells such as microglia and astrocytes at the damage site causes the release of pro-inflammatory cytokines. In the acute phase, neuroinflammatory cascades lead to apoptosis, cell death and pyroptosis, while in later stages these pathways support tissue repair and functional recovery. The ability to control the activation of glial cells and their neuroinflammatory responses has therefore been considered a potential therapeutic strategy for treating neuroinflammatory diseases.  Despite increased scientific attention, the mechanisms of neuroinflammation in cerebral injury are not fully understood due to their complicated and multi-level nature. Following a stroke, neuroinflammation promotes further injury and cell death, but also promotes recovery. Proinflammatory signals from immune mediators activate resident cells and influence the infiltration of inflammatory cells, including neutrophils, monocytes, macrophages and T cells into the ischemic region, thus exacerbating brain damage. For this special topic, we welcome authors from any related basic or clinical field to contribute their original research. These should help to elucidate different neuroinflammation mechanisms in cerebral injury using diverse scientific methods. The main goal of this special issue is therefore to provide the reader with a wide overview of current knowledge in the field of neuroinflammation in cerebral injury. Animal models and clinical experimental procedures may be used to explore novel mechanisms of neuroprotection. Original research reports, review articles, communications and perspectives in all areas pertinent to this topic are welcome.

Yanqiang Wang, Hua Liu and Hongjun Wang
Guest Editors

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.