IMR Press / JIN / Special Issues / CNS_injury

Molecular Mechanisms of Neurodegeneration in the Acute and Chronic Phase of CNS Injury

Submission deadline: 31 July 2022
Special Issue Editor
Michiko Shigyo, PhD
Department of Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA
Interests: neuroscience; molecular biology; neuronal regeneration; spinal cord injury; stem cells; cell culture; neurodegenerative diseases; disease animal models; alzheimer's disease; histology; pharmaceutical sciences
Special Issue Information

Dear Colleagues,

Spinal cord injury (SCI) causes serious irreversible neuropathological damages that lead to sensory and or motor and/or autonomic nervous system dysfunction due to the disruption of the descending and ascending neural tracts. Although it has been reported that adult central nervous system (CNS) axons do not have the plasticity needed to repair lesions through regeneration, numerous studies have suggested that CNS neurons can regenerate and regrowth of injured and/or spared axons may lead to locomotor functional recovery. 
In the SCI, following a traumatic primary injury, secondary biochemical events occur over the time courses of minutes (acute phase) to months/years (chronic phase) and lead to further neurological impairments. Given the complex pathologies of the secondary injury, understanding biochemical and cellular events composed of the secondary injury is crucial for the development of pharmacological interventions and avoiding potential adverse consequences. In a decade, regenerative medicine has been developed as a potential therapeutic strategy to replace the damaged cells or to protect the resident neurons, however, most of the studies showed effectiveness in the acute phase but did not show invariable results in the chronic phase. 
There are still required to accumulate the scientific knowledge gaps between current ongoing clinical trials to treat SCI and the molecular mechanisms including acute and chronic phases.   

In this special issue, we invite the submission of original research articles and review articles that could address the findings of molecular mechanisms underlying neurodegeneration with a perspective of both acute and chronic phases of SCI. 

As an example, novel findings from studies with SCI model organisms demonstrate that the degeneration of neurons may be regulated by specific types of protein expression in the acute SCI but not in the chronic SCI.

Dr. Michiko Shigyo

Guest Editor

spinal cord injury
CNS injury chronic phase
neurodegenerative diseases
neuronal phenotype
functional recovery
molecular mechanisms
cell signaling
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted manuscripts should be well formatted in good English.

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