Neurodegeneration is characterized as the progressive loss of structure or function of neurons, including the ultimate death of neurons. The two most significant disorders that develop following neurodegeneration are Alzheimer’s disease and Parkinson’s disease, for which we do not have adequate understandings of their etiology and pathogenesis at the molecular level to develop effective therapeutic strategies. Inevitably, neurodegeneration occurs in normal aging as well, while there is also a fundamental gap in knowledge on how the degeneration process of neurons is switched on by aging. Our future attempts to develop treatments and cures for neurodegenerative disorders may benefit from addressing the molecular mechanisms of neurodegeneration not only in disease models, but also in a physiological aging condition.
In this special issue, we invite submission of original research articles and review articles that could stimulate the identification of molecular mechanisms underlying neurodegeneration, in both physiological and disease conditions, with a wide range of perspectives. As an example, emerging evidence from studies with model organisms demonstrate that the degeneration of neurons may be regulated non-cell-autonomously by surrounding non-neuronal cells, such as microglia and astrocytes, or even non-neuronal tissues. From a broader perspective, a significant amount of evidence indicates that some aging-related neurodegenerative diseases, especially Parkinson’s disease, are not only a central nervous system disorder but also have systemic pathology and manifestations, suggesting a close link between the non-neuronal periphery and neurodegeneration during aging.
We welcome in vivo, in vitro, and in silico research, as well as clinically oriented studies.
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted manuscripts should be well formatted in good English.