IMR Press / JIN / Special Issues / 1631696192636

Vitamin D and the Nervous System

Submission deadline: 30 April 2022
Special Issue Editor
Giulia Bivona, MD
Section of Clinical Biochemistry and Clincal Molecular Medicine, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo , Palermo , Italy
Interests: Vitamin D synthesis; Metabolisms and biological activities; Laboratory markers in cardiovascular disease; Neurology; Infectious diseases and sepsis; Interactions between immune and nervous systems; Neuron-to-glia communication
Special Issue Information

Dear Colleagues, 

A remarkable body of literature data documents an association between vitamin D and the development of various central nervous system (CNS) diseases. The brain is capable of synthetizing and catabolizing vitamin D, which has been shown to regulate many cellular processes in neurons and microglia. By reducing the synthesis of pro-inflammatory cytokines and the oxidative stress load, vitamin D assists with synaptic plasticity and neurotransmission in dopaminergic neural circuits and exerts anti-inflammatory and neuro-protective activities within the brain. Further, vitamin D action in the brain has been related to the clearance of amyloid plaques, which represent the hallmarks of Alzheimer Disease (AD), by the immune cell. Based on these considerations, many studies have investigated the role of circulating vitamin D levels in patients affected by neurodegenerative diseases, to assess the eventual role of vitamin D as a biomarker or a risk factor in AD and Parkinson Disease (PD). An association between low vitamin D levels and the onset and progression of AD and PD has been reported, and some interventional studies to evaluate the role of vitamin D in preventing disease onset have been performed. However, many pitfalls affected the studies available, including strong discrepancies in the methods used and the lack of standardized data. Despite a large number of studies, it remains unclear whether Vitamin D can have a role in neurodegenerative diseases. This Special Issue aims to collect studies on the role of Vitamin D in AD, PD and other neurodegenerative disorders, both as either a biomarker or a risk factor.

Dr. Giulia Bivona

Guest Editor

Keywords
Vitamin D
Neurodegeneration
Alzheimer disease
Parkinson disease
Biomarkers
Standardization
Risk factor
Pathogenesis
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted manuscripts should be well formatted in good English.

Back to top