IMR Press / JIN / Special Issues / 1617791210607

Metal toxicity and nervous system disorders

Submission deadline: 31 January 2022
Special Issue Editors
Fernanda Leal, MD
Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal
Interests: Metals; Neurodegenerative diseases
Special Issue Information

Dear Colleagues,

The main neurodegenerative diseases, such as Alzheimer′s, Parkinson′s, Huntington′s, amyotrophic lateral sclerosis (ALS) and Prion diseases, present certain similarities, as in the aggregation of disease-specific proteins in the central nervous system (CNS). All these proteins have been shown to interact with metal ions with redox activity. Biometals like copper, iron, manganese, and zinc are crucial for many physiological functions, especially in the CNS. However, at the cerebral level, shifts in the amounts of these metals can lead to the excessive production of reactive oxygen species (ROS), like H2O2 and hydroxyl radicals, and of reactive nitrogen species (RNS), like NO. These free radicals are toxic and, if not removed or neutralized, they react with lipids, proteins, and nucleic acids, damaging several cellular functions, contributing to the intensification of oxidative stress. Toxic metals like aluminum and lead are mainly absorbed and captured by the brain. Unlike biometals, the organism cannot provide homeostatic regulation of toxic metals. These metals exert their toxic effects by competing with essential metals for an active enzyme or a membrane protein sites and by intense reacting with biologically active groups. This Special Issue will focus on metal toxicity and nervous system disorders, the main related pathogenic mechanisms, and possible therapeutic strategies.

Prof. Dr. Fernanda Leal

Guest Editor

Alzheimer’s disease
Parkinson’s disease
Huntington’s disease
Prion diseases
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted manuscripts should be well formatted in good English.

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