IMR Press / JIN / Special Issues / 1617271923828

UPR and heat shock proteins in neurodegenerative and neurological disorders: From mechanism to therapy and bench to bedside

Submission deadline: 01 February 2022
Special Issue Editors
Rohit Gundamaraju, MD
ER stress and mucosal immunology team, School of Health Sciences, University of Tasmania
Interests: UPR; Cancers; Gut; Apoptosis; Cancer progression
Special Issue and Collections in IMR journals
Special Issue Information

Dear Colleagues,

Current research and evidence states that there are numerous novel overlapping pathways shared by neurodegenerative disorders and diseases like cancer. These diseases are defined by a set of molecular determinants that are either complementarily deregulated, or share remarkably overlapping functional paths. The inter-dependent regulation of brain cancers and neurodegeneration, mediated by intercellular communication between tumor and neuronal cells in the brain through the extracellular microenvironment is necessary in understanding this unique connection. One of such pivotal pillar which plays a huge role in both maladies is unfolded protein response (UPR).

The importance of tight protein quality control is elucidated by neurodegenerative disorders where disturbed neuronal proteostasis causes neuronal dysfunction and loss. This highlights the importance of protein quality control in the neuronal endomembrane system, to which the unfolded protein response (UPR) is instrumental. Hence, UPR signalling is vital in normal functioning and a malfunction in such mechanisms leads to development of neurodegenerative disorders. On the other hand, UPR alongside heat shock proteins play a key role not only in protein homeostasis but also in inflammation and diseases progression. Hence, the current special issue focuses on key elements and mechanisms interrelating UPR in neurological disorders which includes but not limited to therapeutics, clinical implications and underlying mechanisms.

The research subtopics of the current theme include:

  1. Unraveling mechanisms for UPR and brain cancers.
  2. Link between neurological cancers and neurodegenerative disorders- the nexus.
  3. UPR and neurological inflammation.
  4. Involvement of heat shock proteins in the progression of neurological disorders.
  5. Clinical studies involving UPR and neurological disorders.
  6. Utilization of herbal isolates or bioactive compounds in impeding the progression of neurological disorders utilizing UPR or stress pathways.
  7. Role of food biotechnology advances.

Dr. Rohit Gundamaraju

Guest Editor

Neurological disorders
Brain cancer
Heat Shock proteins
Neurological therapies
Neurodegenerative disorders
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted manuscripts should be well formatted in good English.

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