- Department of Neurology, Chair of Vascular Neurology, Dementia and Ageing Research, University Hospital Essen, Essen, GermanyInterests: Aged animals models of cerebral ischemia; Behavioral analysis; Recording of EEG and various physiological parameters by telemetric measurements; MRI for small animals; Immunohistochemical procedures, proteomics, genomics
Old age is associated with an enhanced susceptibility to neurodegenerative diseases. Despite the initial hope that cell-based therapies may stimulate restorative processes in the degenerative brain, it is now recognized that aging processes may promote an unfavorable environment for such treatments. Alternatively, in the last several years, many groups have focused on exploiting brain plasticity that is preserved to some extent even in the old brains, to enhance endogenous repair mechanisms of the brain after insults such as traumatic brain injury or cerebral ischemia. The main opponent of brain plasticity in the aged brain is neuroinflammation. With increasing age, the brain It is becoming evident that subtle but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease (cSVD) and subsequently dementia. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity hypertension, diabetes, and atherosclerosis are increasingly understood to act as “silent contributors” to neuroinflammation—not only establishing the condition as a central pathophysiological mechanism, but also constantly fueling it. Acute neuroinflammation, often in the context of traumatic or ischemic CNS lesions, aggravates the acute damage and can lead to a number of pathological illnesses, such as depression, post-stroke dementia and potentially neurodegeneration. All of those sequelae impair recovery and most of them provide the ground for further cerebrovascular events; thus, a vicious cycle develops. We also cover brain vasculature recent advances in signaling pathways that can potentially protect cells as well as treatment options for the maintenance of brain capillaries to prevent diseases associated with brain vasculature remodeling in response to aging and associated comorbidities.
This Special Issue will provide an up-to-date information on molecular, cellular, and behavioral events associated with neurodegenerative diseases and new therapeutic options.
Prof. Dr. Aurel Popa-Wagner
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
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- Impact of Cardiovascular Diseases on Ischemic Stroke OutcomesChrista C. Huber, Xuejun Wang, Hongmin WangJ. Integr. Neurosci. 2022, 21(5), 138; https://doi.org/10.31083/j.jin2105138(This article belongs to the Special Issue Translational bottleneck for stroke therapy: impact of aging and co-morbidities)6Download175Views