IMR Press / JIN / Special Issues / 1615364138374

Non-medication treatment for medically intractable epilepsy

Submission deadline: 31 January 2022
Special Issue Editors
Ayataka Fujimoto, MD, PhD
Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Japan
Interests: Epilepsy; Neurosurgery; Neurpsychology; Brain tumor; Pediatric neurology; Pediatric neurosurgery
Tohru Okanishi, MD
Division of Child Neurology, Brain and Neuroscience, Faculty of Medicine, Tottori University, Tottori, Japan
Interests: Pediatric epilepsy; Epilepsy surgery; Pediatric neurology; Neuroimaging; Tuberous sclerosis
Special Issue Information

Dear Colleagues,

Thanks to the latest anti-seizure medication (ASM), medication therapy can control epileptic seizures in many patients who have epilepsy, and it is said that about 70-80% of them can obtain freedom from seizures by ASMs. Comparing the old ASMs that include enzyme inducers, current ASMs have fewer side effects, and have good efficacy rates. However, even though ASMs contribute to the field of epilepsy, the rest of the patients with epilepsy cannot obtain freedom from seizures with ASMs alone, and need to choose other treatment options, such as epilepsy surgery, vagus nerve stimulation, ketogenic diet therapy, deep brain stimulation, responsive neurostimulation therapy, etc
In terms of the non-medication treatment, seizure prediction might be one of the promising interventions. We already have seizure predicting canines. We may have devices to predict seizures in the near future.
The aim of this special issue is to focus on the non-medication treatment (prediction of seizures, epilepsy surgery, VNS, RNS, etc. in epilepsy treatment, basic research, medical engineering, etc.) for medically intractable epilepsy.

Dr. Ayataka Fujimoto and Dr. Tohru Okanishi

Guest Editors

Responsive neurostimulation therapy (RNS)
Seizure prediction
Epilepsy surgery
Vagus nerve stimulation therapy(VNS)
Ketogenic diet therapy
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted manuscripts should be well formatted in good English.

Planned Paper (3 Papers)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to IMR Press journals will subject to peer-review before acceptance

Epilepsy surgery

Yosuke Masuda

Ketogenic diet

Rika Suzumura

Vagus nerve stimulation

Sotaro Kanai

Published Paper (4 Papers)
Open Access Original Research
Effects of Stevia rebaudiana Bertoni extracts in the rat model of epilepsy induced by pentylenetetrazol: Sirt-1, at the crossroads between inflammation and apoptosis
Eman M. El Nashar, Walaa Obydah, Mansour A. Alghamdi, Somaya Saad, ... Abdelaziz M. Hussein
J. Integr. Neurosci. 2022, 21(1), 021;
(This article belongs to the Special Issue Non-medication treatment for medically intractable epilepsy)
Open Access Original Research
Transcriptomic profile of epileptic children treated with ketogenic therapies
Jana Ruiz-Herrero, Gloria Olaso-Gonzalez, Eva Serna, Elvira Cañedo-Villarroya, ... Jose Vina
J. Integr. Neurosci. 2022, 21(1), 031;
(This article belongs to the Special Issue Non-medication treatment for medically intractable epilepsy)
Open Access Original Research
Neuropsychological performance after carotid endarterectomy
Lenka Krámská, Martin Kovář, Lucia Hrešková, Martin Jerie
J. Integr. Neurosci. 2022, 21(1), 036;
(This article belongs to the Special Issue Non-medication treatment for medically intractable epilepsy)
Open Access Case Report
Surgical aspects using an exoscope for corpus callosotomy: initial experience for epilepsy surgery
Kyoichi Tomoto, Toshiki Nozaki, Chikanori Inenaga, Ayataka Fujimoto
J. Integr. Neurosci. 2022, 21(1), 039;
(This article belongs to the Special Issue Non-medication treatment for medically intractable epilepsy)
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