Dear Colleagues,

Thanks to the latest anti-seizure medication (ASM), medication therapy can control epileptic seizures in many patients who have epilepsy, and it is said that about 70-80% of them can obtain freedom from seizures by ASMs. Comparing the old ASMs that include enzyme inducers, current ASMs have fewer side effects, and have good efficacy rates. However, even though ASMs contribute to the field of epilepsy, the rest of the patients with epilepsy cannot obtain freedom from seizures with ASMs alone, and need to choose other treatment options, such as epilepsy surgery, vagus nerve stimulation, ketogenic diet therapy, deep brain stimulation, responsive neurostimulation therapy, etc. 
In terms of the non-medication treatment, seizure prediction might be one of the promising interventions. We already have seizure predicting canines. We may have devices to predict seizures in the near future.
The aim of this special issue is to focus on the non-medication treatment (prediction of seizures, epilepsy surgery, VNS, RNS, etc. in epilepsy treatment, basic research, medical engineering, etc.) for medically intractable epilepsy.

Dr. Ayataka Fujimoto and Dr. Tohru Okanishi

Guest Editors

Manuscripts should be submitted via our online editorial system at https://jour.ipublishment.com/imr/access/login by registering and logging in to this website. Once you are registered, click here to start your submission Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted papers should be well formatted and use good English.