IMR Press / JIN / Special Issues / 1613371437074

 Ischemic stroke: new diagnostic tools and therapeutic strategies in the era of recanalization

Submission deadline: 31 January 2022
Special Issue Editors
Juan Salom, PhD
Joint Unit for Cerebrovascular Research, La Fe Health Research Institute, Valencia, Spain; Department of Physiology, University of Valencia, Valencia, Spain
Interests: Ischemic stroke; Animal models; Ischemic brain damage; Cell senescence; Neuroprotection; New therapies
Ramón Iglesias-Rey, PhD
Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Clinical University Hospital (CHUS), SERGAS, Travesía da Choupana, s/n, Santiago de Compostela, Spain
Interests: Cerebral ischemia; New therapeutic strategies based on magnetocaloric materials, Mapping of brain temperature and magnetic resonance imaging
Special Issue Information

Dear Colleagues,

Stroke remains a global leading cause of death and permanent disability. Ischemic stroke is by far the most common kind of stroke, accounting for more than 85% of all strokes. Large vessel occlusions (LVOs), defined as blockages of the proximal intracranial anterior and posterior circulation, account for more than 40% of ischemic strokes.  Intravenous thrombolysis with rtPA used to be the only reperfusion therapy. However, endovascular therapies including mechanical thrombectomy has revolutionized acute care of LVOs. This opens opportunities for the reevaluation of the entire chain of stroke care delivery, including diagnosis, neuroprotection and neuroreparation in the context of the neurovascular unit.

The present special issue welcomes papers on ischemic stroke, with special focus on, but not limited to, preclinical and clinical studies which results could pave the way for accurate diagnostic as well as effective neuroprotection and neuroreparation. A non-exclusive inspiring list of subjects could be the improvement of recanalization therapies, new thrombolytic agents, and reevaluation of neuroprotective compounds in the light of new standards for a rigorous preclinical testing. Non-drug based approaches, such as ischemic tolerance and hypothermia should also be considered. In this line, nano-drug delivery platforms will be positively assessed. Post-stroke neuroregeneration boosted by stem-cell based interventions is also a promising field. Finally, research works based on molecular imaging for diagnosis, prognosis, and evaluation of ischemic damage are suitable for this issue.

Dr. Juan B. Salom and Dr. Ramón Iglesias-Rey

Guest Editors

Ischemic stroke
Ischemic brain damage
Magnetic Resonance Imaging (MRI)
Molecular imaging
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted manuscripts should be well formatted in good English.

Published Paper (1 Paper)
Open Access Short Communication
Mechanical thrombectomy in patients with stroke due to large vessel occlusion in the anterior circulation and low baseline NIHSS score
Andrea M. Alexandre, Iacopo Valente, Giovanni Frisullo, Roberta Morosetti, ... Aldobrando Broccolini
J. Integr. Neurosci. 2021, 20(3), 645–650;
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