Multiple sclerosis (MS) is an autoimmune disease of the central nervous system and is one of the most common causes of disability in young adults. From a pathological perspective a triad of inflammation, demyelination and neurodegeneration characterizes this disease. MS patients can suffer from a plethora of symptoms, among which stand the sensorimotor, cerebellar, emotional and cognitive manifestations. The last decade has witnessed an impressive pharmacological development that has offered more efficient therapeutic strategies that the ones available in the last century. Despite these advances, several symptoms remain unnoticed, are poorly assessed and lack adequate treatment. In this context fatigue, pain, sleep disorders, emotional disturbances and cognitive manifestations could be perceived as “silent symptoms” that could seriously alter the quality of life of MS patients and are usually overlooked in this population.
Therefore, research is highly needed in order to properly address the pathophysiology of these symptoms, propose new screening tools and most importantly assess innovative therapeutic interventions.
The aim of this Research Topic is to shed light on the utility of innovative approaches in MS. This concerns original research that applies clinical, molecular, cellular, or neuroimaging approaches to unravel the underlying mechanisms of MS-related symptoms. In addition, testing new pharmacological agents or alternative interventions in this context would be of great interest. Review articles that analyze the current literature on the above-mentioned topics are welcomed. Case reports also fall within the scope of this subject. Research involving animal models of MS would also be considered.
Furthermore, works that aim to explore the brain physiology in this disease allows a better understanding of the underlying mechanisms of MS related symptoms, and would pave the way to the development of objective tools to monitor their clinical evolution and therapeutic responses.
Dr. Samar S. Ayache and Dr. Moussa Chalah
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 1900 USD. Submitted manuscripts should be well formatted in good English.
- Vitamin D, Epstein-Barr virus, and endogenous retroviruses in multiple sclerosis - facts and hypothesesChristine Brütting, Gabriele I. Stangl, Martin S. StaegeJ. Integr. Neurosci. 2021, 20(1), 233–238; https://doi.org/10.31083/j.jin.2021.01.392(This article belongs to the Special Issue Advances in multiple sclerosis research)220Download5Citations608Views
- Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: an explorative studyIrini Vilou, Christos Bakirtzis, Artemios Artemiadis, Panagiotis Ioannidis, ... Nikolaos GrigoriadisJ. Integr. Neurosci. 2020, 19(2), 341–347; https://doi.org/10.31083/j.jin.2020.02.35(This article belongs to the Special Issue Advances in multiple sclerosis research)64Download4Citations250Views