Alzheimer's disease (AD) is one of the most debilitating neurodegenerative diseases of our times affecting many brain areas including those center regulating thought, memory, motor tasks, and language. In 2014, 5 million of the population in USA were living with AD and it is expected to reach 14 million by 2060. In this disease, amyloid- β (Aβ) accumulates to form plaques, and tau aggregates to form tangles. During this process pathological signaling cascades are also activated by inflammation, oxidative stress, enzymatic process etc. An interesting manuscript reviewed by Hampel et al. 2010 showed that interventions that slow down the clinical onset of dementia by 1 year would decrease the prevalence of AD by 9 million cases in 2050. However, little is known about the disease and progression of AD.
Because of the lack of appropriate cure targeting AD, families are facing economic burden and mental disturbance. For instance, in 2040, these costs are projected to jump to between $379 and more than $500 billion annually. In addition, it is well established that AD is one of the top 10 leading cause of death in the United States. This special issue particularly focuses on the mechanisms to dissect Alzheimer’s diseases by converging different perspectives together. We believe that by advancing the currents state of knowledge, one could formulate a better strategy of therapeutic intervention. Journal of Integrative Neuroscience (JIN) encourages both the submission original discovery and use of the latest tools and technology in the field of AD. We are highly enthusiastic to welcome the manuscripts that preferentially fall under this topic to advance the field forward.
In summary, we encourage researchers and academicians all around the world to disseminate their original findings in the form of research papers, mini-reviews, opinions, letter to editors, short communication towards stimulating diagnosis, nature, cause, therapeutic interventions and public health aspects of AD issues.
Dr. Dhruba Pathak
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted manuscripts should be well formatted in good English.
- Open Access Original ResearchDanggui-Shaoyao-San Promotes Amyloid-β Clearance through Regulating Microglia Polarization via Trem2 in BV2 CellsGongcan Chen, Mengmeng Han, Yi Chen, Yaling Lei, ... Xiang ChangJ. Integr. Neurosci. 2023, 22(3), 72; https://doi.org/10.31083/j.jin2203072(This article belongs to the Special Issue Alzheimer’s disease (AD))5Downloads36Views
- Open Access Original ResearchIdentification, characterization and expression profiles of PSEN2 in the Chinese tree shrew (Tupaia belangeri chinensis)Mingxue Li, Wenguang Wang, Dexuan Kuang, Leiying Ruan, ... Caixia LuJ. Integr. Neurosci. 2020, 19(2), 249–257; https://doi.org/10.31083/j.jin.2020.02.28(This article belongs to the Special Issue Alzheimer’s disease (AD))26Downloads1Citations99Views