Background: The cingulo-opercular network (CON) has been proposed to play a central role in cognitive control. The lifetime change mechanism of its integrity and interaction with other cognitive control-related functional networks (CCRNs) is closely associated with developing cognitive control behaviors but needs further elucidation. Methods: The resting-state functional magnetic resonance imaging data were recorded from 207 subjects, who were divided into three age groups: age 4–20, 21–59, and 60–85 years old. For each group, multiple indices (cross-correlation, total independence, and Granger causality) within CON and between CON and other cognitive control-related functional networks (dorsal attention network, DAN; central executive network, CEN; default mode network, DMN) were calculated and correlated with age to yield maps that delineated the changing pattern of CON-related interaction. Results: We found three main results. (1) The connectivity indices within the CON and between CON and the other three CCRNs showed significant enhancement from childhood to early adulthood (age 4–20 years), (2) mild attenuation within CON from early adulthood to middle age (age 21–59 years), and (3) significant attenuation within CON and between CON and DMN in the elder group (age 60–85 years). Conclusions: The results indicated the prominently increased integrity of within-CON and CON-CCRNs communication, mildly weakened within-CON communication, and significantly attenuated within-CON and CON-DMN communication, characterizing distinct changing patterns of CON-interaction at three different stages that covered a life-long span.