Academic Editor: Rafael Franco
Objective: This study aimed to conduct proteomic analysis of the
sphincter in a neurogenic bladder caused by T10 spinal cord injury. The
differentially expressed proteins (DEPs) of the sphincters
(internal urethral sphincter) in the
neurogenic bladders (NBs) of rats after complete transection of the T10 spinal
cord segment were screened using tandem mass tag (TMT)-based quantitative
labeling, and their biological information was analyzed. Methods: Twelve
adult Sprague Dawley rats out of 40 were randomly assigned to the blank group
(n = 12), while the remaining 28 were placed in the T10 spinal cord
injury model via modified Hassan Shaker spinal cord transection; 12 of these rats
were then randomly selected as the model group. The rats in both groups underwent
urodynamics detection and hematoxylin and eosin (H&E) staining. The proteins
expressed in the bladder sphincter were detected using TMT-based quantitative
proteomics. DEPs were defined as proteins with fold change