IMR Press / JIN / Volume 21 / Issue 5 / DOI: 10.31083/j.jin2105139
Open Access Commentary
Magnetic Resonance Imaging throughout the Clinical Course of Schizophrenia: Neurobiological Underpinnings and Clinical Implications
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1 Department of Clinical Psychology, Fourth Military Medical University, 710032 Xi’an, Shaanxi, China
2 Department of Computer Science, Tufts University, Medford, MA 02155, USA
3 MOE Frontiers Center for Brain Science, Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, 200433 Shanghai, China
4 Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, 710032 Xi’an, Shaanxi, China
5 The Second Medical Center, Chinese PLA General Hospital, 100853 Beijing, China
*Correspondence: (Long-Biao Cui); (Feng Cao); (Di Wu)
These authors contributed equally.
Academic Editor: Hsien-Yuan Lane
J. Integr. Neurosci. 2022, 21(5), 139;
Submitted: 19 March 2022 | Revised: 27 April 2022 | Accepted: 13 May 2022 | Published: 27 July 2022
Copyright: © 2022 The Author(s). Published by IMR Press.

This is an open access article under the CC BY 4.0 license.


As a non-invasive detection method and an advanced imaging method, magnetic resonance imaging (MRI) has been widely used in the research of schizophrenia. Although a large number of neuroimaging studies have confirmed that MRI can display abnormal brain phenotypes in patients with schizophrenia, no valid uniform standard has been established for its clinical application. On the basis of previous evidence, we argue that MRI is an important tool throughout the whole clinical course of schizophrenia. The purpose of this commentary is to systematically describe the role of MRI in schizophrenia and to provide references for its clinical application.

magnetic resonance imaging
clinical application
Fig. 1.
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