IMR Press / JIN / Volume 20 / Issue 4 / DOI: 10.31083/j.jin2004100
Open Access Short Communication
Altered cortical activity in patients with lower limb amputation based on EEG microstate
Xinying Shan1,2,*,†Conghui Wei3,†Shaowen Liu3,†Jun Luo3,*
Show Less
1 School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China
2 Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, 100176 Beijing, China
3 Department of Rehabilitation Medicine, The Second Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, China

These authors contributed equally.

J. Integr. Neurosci. 2021, 20(4), 993–999; https://doi.org/10.31083/j.jin2004100
Submitted: 23 August 2021 | Revised: 3 October 2021 | Accepted: 26 October 2021 | Published: 30 December 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract

Previous studies have revealed significant changes in electroencephalogram (EEG) microstates in neuropsychiatric diseases, including schizophrenia, depression, and dementia. To explore the resting-state EEG microstate with amputation, we collected the EEG datasets from 15 patients with lower limb amputation and 20 healthy controls. Then, we analyzed the parameters of four classical EEG microstates (A–D) between the two groups. Specifically, the parameters were statistically analyzed, including duration, occurrence rate, time coverage, and transition rate. According to the results, the duration of microstate C (t = 2.95, p = 0.005) in the lower limb amputation group was significantly smaller compared with the control group, while the occurrence rate of microstate B (t = –2.22, p = 0.03) and D (t = –3.35, p = 0.002) were significantly larger in the lower limb amputation group. In addition, the transition rate of microstate differed significantly in AC, CA, DB between the two groups. Our results implied: (1) amputation has changed the resting-state EEG microstate; (2) EEG microstate analysis can be an approach to explore the alteration of cortical function.

Keywords
EEG microstate
Lower limb amputation
Resting-state EEG
Brain plasticity
Figures
Fig. 1.
Share
Back to top