Relationships among language ability, arcuate fasciculus and lesion volume were
investigated by use of diffusion tensor tractography in patients with putaminal
hemorrhage. Thirty-three right-handed patients within six weeks of hemorrhage
onset were recruited. Correlation of the aphasia quotient with subset (fluency,
comprehension, repetition, naming) scores, diffusion tensor tractography
parameters and lesion volume of patients, aphasia quotient (r = 0.446)
with subset (naming: r = 0.489) score had moderate positive correlations
with fractional anisotropy of the left arcuate fasciculus. The aphasia quotient
subset (repetition) score had a strong positive correlation with fractional
anisotropy of the left arcuate fasciculus (r = 0.520), whereas, aphasia
quotient subset (fluency and comprehension) scores had no significant
correlations with fractional anisotropy of the left arcuate fasciculus after
Benjamini–Hochberg correction. Aphasia quotient (r = 0.668) with subset
(fluency: r = 0.736, comprehension: r = 0.739, repetition:
r = 0.649, naming: r = 0.766) scores had strong positive
correlations with the tract volume of the left arcuate fasciculus and strong
negative correlations with lesion volume (r = –0.521, fluency:
r = –0.520, comprehension: r = –0.513, repetition: r =
–0.518, naming: r = –0.562). Fractional anisotropy of the left arcuate
fasciculus had a moderate negative correlation with lesion volume (r =
–0.462), whereas the tract volume of the left arcuate fasciculus had a strong
negative correlation with lesion volume (r = –0.700). According to the
result of mediation analysis, tract volume of the left arcuate fasciculus fully
mediated the effect of lesion volume on the aphasia quotient. Regarding the
receiver operating characteristic curve, the lesion volume cut-off value was
29.17 cm
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Relationships among language ability, the arcuate fasciculus and lesion volume in patients with putaminal hemorrhage: a diffusion tensor imaging study
Min Jye Cho1, Sung Ho Jang1,*
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1
Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 705-717 Namku, Taegu, Republic of Korea
*Correspondence: strokerehab@ynu.ac.kr (Sung Ho Jang)
J. Integr. Neurosci. 2021, 20(3), 677–685;
https://doi.org/10.31083/j.jin2003072
Submitted: 29 April 2021 | Revised: 14 May 2021 | Accepted: 22 July 2021 | Published: 30 September 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Arcuate fasciculus
Lesion volume
Language ability
Diffusion tensor tractography
Diffusion tensor imaging
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