Sleep deprivation has deteriorating effects on cognitive functions and
activation of brain inflammation mechanisms has been reported by some studies
following total sleep deprivation. Some studies have reported the health benefits
of punicalagin, a main abstract from Punica granatum L., including those for the
treatment of Alzheimer’s disease. The antioxidant characteristic of punicalagin
and the fact that sleep deprivation accelerates mediators of inflammation led us
to further explore the possible neuroprotective role of punicalagin in total
sleep deprivation memory impairment in a rat model. In this study, male Wistar
rats were implanted with a canula in the lateral ventricle to receive
intracerebroventricular injections (drug or vehicle). The animals were trained
for the passive avoidance test and then received intracerebroventricular
injections of different doses of punicalagin (0.001, 0.01, or 0.1
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Original Research
Punicalagin effect on total sleep deprivation memory deficit in male Wistar rats
Mohammad Nasehi1, Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani2, Mohammad-Reza Zarrindast1, Shahram Zarrabian3,*
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1
Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, 18116-94784 Tehran, Iran
2
Institute for Cognitive Science Studies (ICSS), 16583-44575 Tehran, Iran
3
Department of Anatomical Sciences & Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, 19395-1495 Tehran, Iran
*Correspondence: szarrabian@gmail.com; szarrabian@iautmu.ac.ir (Shahram Zarrabian)
J. Integr. Neurosci. 2021, 20(1), 87–93;
https://doi.org/10.31083/j.jin.2021.01.378
Submitted: 8 October 2020 | Revised: 21 December 2020 | Accepted: 23 February 2021 | Published: 30 March 2021
Copyright: © 2021 The Authors. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Punicalagin (PG)
Total sleep deprivation (TSD)
Memory deficit
Male rats
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