The thyrotroph embryonic factor gene is a circadian
clock-controlled gene. The rs738499 polymorphism of this gene has
been suggested to be associated with depression and sleep disturbance in
Parkinson’s disease in previous cross-sectional studies. We aimed to investigate
whether this single nucleotide polymorphism is associated with the progression
rates of various motor and non-motor symptoms in patients with Parkinson’s
disease. We recruited 186 patients with Parkinson’s disease for a longitudinal
study. Motor and non-motor symptoms were assessed at baseline and follow-up, and
170 Parkinson’s disease patients completed the clinical evaluation twice with an
average follow-up period of 3.3
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Original Research
Thyrotroph embryonic factor polymorphism predicts faster progression of Parkinson’s disease in a longitudinal study
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1
Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, 210029 Jiangsu Province, P. R. China
2
Department of Neurology, Shanghai East Hospital Affiliated to Tongji University, 150 Jimo Road, Pudong New Area, 201200 Shanghai, P. R. China
3
Department of Clinical Laboratory, Affiliated Brain Hospital of Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, 210029 Jiangsu Province, P. R. China
*Correspondence: liuweiguo1100@sina.com (Wei-Guo Liu)
J. Integr. Neurosci. 2021, 20(1), 95–101;
https://doi.org/10.31083/j.jin.2021.01.366
Submitted: 2 November 2020 | Revised: 10 December 2020 | Accepted: 12 January 2021 | Published: 30 March 2021
Copyright: © 2021 The Authors. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Parkinson’s disease
Sleep
Thyrotroph embryonic factor
Circadian genes
Longitudinal study