\gamma-Aminobutyric acid type A receptors (GABA{}_{\text{A}}Rs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition. In specific brain cells, such as in the hippocampus, one of the subtypes of GABA{}_{\text{A}}Rs, the \delta subunit containing GABA{}_{\text{A}}Rs (\delta-GABA{}_{\text{A}}Rs), is predominantly expressed and located in extrasynaptic or perisynaptic positions. \delta-GABA{}_{\text{A}}Rs mediate a slow constant inhibitory current called tonic inhibition. While \delta-GABA{}_{\text{A}}Rs and tonic inhibition is critical for the excitability of single neurons, accumulating data suggest that the function of \delta-GABA{}_{\text{A}}Rs are broader and includes an integrative role in the network oscillations. While these open new horizons on the neurobiology of \delta-GABA{}_{\text{A}}Rs, the complexity continues to challenge the analysis of GABA{}_{\text{A}}Rs and their subtypes. This review will summarize the current knowledge of molecular, cellular and physiological characteristics of \delta-GABA{}_{\text{A}}Rs during health and disease.