Erythropoietin has been researched for its neuroprotective effects in ischemic stroke for over 30 years. Although erythropoietin can cause side effects that need to be controlled, it has been suggested to be effective in enhancing the prognosis of patients who are out of the therapeutic time window and have not received recombinant tissue plasminogen activator therapy. Studies on the mechanism of the function of erythropoietin have shown that it has various protective effects in ischemic brain injury after stroke, including promoting neurogenesis. In this review, we discuss the effects of erythropoietin on neurogenesis after ischemic brain injury and provide references for effective treatments for ischemic stroke, which is one of the leading causes of death worldwide.
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The effects of erythropoietin on neurogenesis after ischemic stroke
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1
Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, P. R. China
2
Beijing Geriatric Medical Research Center and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, 100053, P. R. China
3
Beijing Institute for Brain Disorders, Beijing, 100053, P. R. China
*Correspondence: yumin111@ccmu.edu.cn (Yu-Min Luo); wrongliang@163.com (Rong-Liang Wang)
J. Integr. Neurosci. 2020, 19(3), 561–570;
https://doi.org/10.31083/j.jin.2020.03.4
Submitted: 7 January 2020 | Revised: 18 June 2020 | Accepted: 28 June 2020 | Published: 30 September 2020
(This article belongs to the Special Issue Exploration of mechanisms in cortical plasticity)
Copyright: © 2020 Zhang et al. Published by IMR Press.
This is an open access article under the CC BY-NC 4.0 license (https://creativecommons.org/licenses/by-nc/4.0/).
Abstract
Keywords
Erythropoietin
neurogenesis
ischemic stroke
clinical translation
neurology