MicroRNAs are reportedly involved in the pathogenesis of neurodegenerative
diseases, including Parkinson’s disease and multiple system atrophy. We
previously identified 7 differentially expressed microRNAs in Parkinson’s disease
patients and control sera (miR-30c, miR-31, miR-141, miR-146b-5p, miR-181c,
miR-214, and miR-193a-3p). To investigate the expression levels of the 7 serum
microRNAs in Parkinson’s disease and multiple system atrophy, 23 early
Parkinson’s disease patients (who did not take any anti- Parkinson’s disease
drugs), 23 multiple system atrophy patients, and 24 normal controls were
recruited at outpatient visits in this study. The expression levels of the 7
microRNAs in serum were detected using quantitative real-time polymerase chain
reaction. A receiver operating characteristic curve was used to evaluate whether
microRNAs can differentially diagnose Parkinson’s disease and multiple system
atrophy. Clinical scales were used to analyze the correlations between serum
microRNAs and clinical features. The results indicated that miR-214 could
distinguish Parkinson’s disease from the controls, and another 3 microRNAs could
differentiate multiple system atrophy from the controls (miR-141, miR-193a-3p,
and miR-30c). The expression of miR-31, miR-141, miR-181c, miR-193a-3p, and
miR-214 were lower in multiple system atrophy than in Parkinson’s disease (all
P
Cite this article
89
Downloads
11
Citations
259
Views
Announcements
Open Access
Original Research
Identification of microRNAs for the early diagnosis of Parkinson’s disease and multiple system atrophy
Jia-Hui Yan1, Ping Hua2, Yong Chen3, Lan-Ting Li2, Cui-Yu Yu2, Lei Yan2, Hui Zhang1, Ying He1, Hao Zheng1, Hui Chen1, Zhao-Jing Zhang1, Qi-Hui Yao2, Hui Dong1,*, Wei-Guo Liu2,*
Show Less
1
Department of Medical Genetics and Cell Biology, School of Basic Medicine, Zhengzhou University, No. 100 Science Avenue, Zhengzhou, Henan Province, 450001, P. R. China
2
Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, Jiangsu Province, 210029, P. R. China
3
Laboratory, Affiliated Brain Hospital of Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, Jiangsu Province, 210029, P. R. China
*Correspondence: donghui@zzu.edu.cn (Hui Dong); wgliunbh@sina.com (Wei-Guo Liu)
J. Integr. Neurosci. 2020, 19(3), 429–436;
https://doi.org/10.31083/j.jin.2020.03.163
Submitted: 25 May 2020 | Revised: 22 August 2020 | Accepted: 25 August 2020 | Published: 30 September 2020
Copyright: © 2020 Yan et al. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Parkinson’s disease
multiple system atrophy
serum
microRNA
biomarkers
neurodegenerative disease
Figures
Fig. 1.