The relationship between chronic bacterial colonization in the brain and
Alzheimer’s disease is attracting extensive attention. Recent studies indicated
that the components of bacterial biofilm drive the amyloid-
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Original Research
Muramyl dipeptide promotes Aβ1-42 oligomer production via the nod2/p-p38 mapk/bace1 signaling pathway in the sh-sy5y cells
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1
Geriatrics Department of Chinese Medicine, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China
2
Geriatrics Department of Chinese Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, P. R. China
3
Department of Chinese Medicine, East Hospital, Tongji University, Shanghai, 310000, P. R. China
*Correspondence: doctorymli@163.com (Ya-Ming Li); cyzhang0810@163.com (Chun-Yan Zhang)
J. Integr. Neurosci. 2020, 19(3), 421–428;
https://doi.org/10.31083/j.jin.2020.03.112
Submitted: 22 April 2020 | Revised: 12 July 2020 | Accepted: 14 July 2020 | Published: 30 September 2020
Copyright: © 2020 Chen et al. Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Alzheimer’s disease
Muramyl dipeptide
Nucleotide-binding oligomerization domain 2
β-site APP cleaving enzyme 1
Aβ1-42 oligomer
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