IMR Press / JIN / Volume 19 / Issue 2 / DOI: 10.31083/j.jin.2020.02.1152
Open Access Original Research
The Chinese Herb Codonopsis pilosula Isolate Isorhapontigenin protects against oxidative stress injury by inhibiting the activation of PI3K/Akt signaling pathway
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1 Department of Neurology, First Hospital of Lanzhou University, Lanzhou City, Gansu Province, 730000, P. R. China
*Correspondence: (Youquan Gu)
J. Integr. Neurosci. 2020, 19(2), 333–340;
Submitted: 14 August 2019 | Revised: 3 March 2020 | Accepted: 16 March 2020 | Published: 30 June 2020
Copyright: © 2020 Gu et al. Published by IMR press.
This is an open access article under the CC BY-NC 4.0 license

We investigated the effects of the Chinese herb Codonopsis pilosula isolate isorhapontigenin on antioxidant factor and the PI3K/Serine/Akt signaling pathway in Parkinson's disease. This research was, therefore, carried out to explore a possible protective mechanism of isorhamnetin in Parkinson's disease. The results support that isorhapontigenin could effectively inhibit isorhapontigenin restored myeloperoxidase + induced reduction of antioxidant levels. Also, 1-Methyl-4-phenylpyridine up-regulated the expression of phosphorylated-Akt, phosphorylated-PI3K, and phosphorylated mammalian target of rapamycin, while isorhapontigenin inhibited the expression of phosphorylated-Akt, phosphorylated-PI3K, and phosphorylated- mammalian target of rapamycin. Furthermore, LY294002 improved the antioxidant effect of isorhapontigenin in PC12 cells, and insulin-like growth factor 1 inhibited the antioxidant effect of isorhapontigenin in PC12 cells. Our results support the finding that isorhamnetin enhanced the antioxidant effect induced by 1-Methyl-4-phenylpyridine in PC12 cells by suppressing the activation of the PI3K/Akt signaling pathway.

oxidative stress
Parkinson's disease
PI3K/Akt signaling pathway
traditional Chinese medicine
Codonopsis pilosula
Figure 1.
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