IMR Press / JIN / Volume 18 / Issue 3 / DOI: 10.31083/j.jin.2019.03.193
Open Access Original Research
Contingent negative variation for the periodicity of migraine attacks without aura
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1 Department of Senile Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P. R. China
2 Department of Geriatrics, The Central Hospital of Taian, Taian 271000, Shandong, P. R. China
3 Department of Ophthalmology, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, Shandong, P. R. China
*Correspondence: (Xueping Liu)
J. Integr. Neurosci. 2019, 18(3), 269–276;
Submitted: 28 June 2019 | Accepted: 23 August 2019 | Published: 30 September 2019
Copyright: © 2019 Tian et al. Published by IMR press.
This is an open access article under the CC BY-NC 4.0 license

Migraine is a primary neuropsychological disorder, although its etiology and pathogenesis are unknown. It has been reported that using contingent negative variation, the periodicity of migraine attacks is three days in adults. However, there is still a lack of relevant reports about the periodicity of migraine without aura in adults. Therefore, we investigated the changes of contingent negative variation in adults with migraine without aura from three to seven days after migraine attacks in order to provide the basis for exploring the circulation periodicity of migraine without aura. This prospective, observational study involved a group of 34 individuals with migraine without aura, who were screened during the three to seven days after a migraine attack without aura. A healthy group (31 individuals) was used as controls to assess the amplitudes of contingent negative variation and habituation of early contingent negative variation. Indices of the amplitudes included overall contingent negative variation, initial contingent negative variation, terminal contingent negative variation, and postoperative negative contingent variation. Differences between these indicators were analyzed. No significant difference was found between the patient and control groups for either the amplitudes of these measures of contingent negative variation or habituation of the early contingent negative variation for three to seven days after a migraine attack without aura (all P > 0.05). Thus, the study reported here found that the periodicity of migraine attacks without aura in adults is more than three days.

circulation periodicity
Figure 1.
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