IMR Press / JIN / Volume 18 / Issue 2 / DOI: 10.31083/j.jin.2019.02.122
Open Access Original Research
MST1 suppresses viability and promotes apoptosis of glioma cells via upregulating SIRT6 expression
Show Less
1 Department of Endoscopic Center, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province 310022, P. R. China
2 Department of Neurological Tumor Surgery, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy;of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province 310022, P. R. China
3 Departement of Internal Medicine, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province 310022, P. R. China
*Correspondence: zhudp@zjcc.org.cn (Dapeng Zhu)
J. Integr. Neurosci. 2019, 18(2), 117–126; https://doi.org/10.31083/j.jin.2019.02.122
Submitted: 9 January 2019 | Accepted: 4 June 2019 | Published: 30 June 2019
Copyright: © 2019 Zhu et al. Published by IMR press.
This is an open access article under the CC BY-NC 4.0 license (https://creativecommons.org/licenses/by/4.0/)
Abstract

It has been well established that mammalian sterile 20-like 1 (MST1) functions as a suppressor via regulating cell progression in many tumors. However, the molecular mechanism of MST1 on regulating glioma progression remains unclear. Here, we discovered that MST1 was robustly down-regulated in glioma tissues and cells. Functional analysis showed that over-expression of MST1 downregulated viability and colony formation and promoted apoptosis of glioma cells. Our results also identified that MST1 positively regulated expression of SIRT6 (Sirtuin 6) via transcriptional factor FOXO3a (Forkhead box O3a). Furthermore, the functional role of MST1 in glioma cell viability (or apoptosis) were significantly reversed after knocking down of SIRT6. Our research indicates that MST1 is a potential biomarker for the prognosis and diagnosis of glioma and provides new direction on the molecular mechanism of glioma progression and development.

Keywords
Glioma
mammalian sterile 20-like 1
Sirtuin 6
viability
apoptosis
molecular mechanisms
immunohistochemistry
Figures
Figure 1.
Share
Back to top