IMR Press / FBS / Volume 5 / Issue 1 / DOI: 10.2741/S368

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Cellular basis of hepatic fibrosis and its role in inflammation and cancer
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1 Division of Liver Diseases, Mount Sinai School of Medicine, New York, USA
Academic Editor:Rajagopal N. Aravalli
Front. Biosci. (Schol Ed) 2013, 5(1), 217–230;
Published: 1 January 2013
(This article belongs to the Special Issue Molecular and cellular mechanisms of hepatocarcinogenesis)

Multiple etiologies of liver injury can lead to fibrosis, which results from an imbalance between production and resorption of extracellular matrix. Hepatic stellate cells (HSCs), resident vitamin A storing cells, play a vital role in the response to injury. Upon activation, HSCs orchestrate the responsiveness of the liver to different types of injury, leading to deposition of excessive scar matrix into the interstitium as a wound-healing response. Quantitatively and qualitatively, the altered extracellular matrix (ECM) provides a permissive milieu for the development of cellular dysplasia and ultimately hepatocellular carcinoma (HCC). There is a range of underlying mechanisms that contribute to progression of fibrosis to HCC. As the functional complexity of HSC activation and its roles in inflammation, immune responses, angiogenesis, and proliferation are being clarified, new advances in therapeutic options for patients with chronic liver disease are emerging.

Liver fibrosis
Hepatic stellate cells
Extracellular Matrix
Hepatocellular Carcinoma
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